A study to find the effects of a drug-Mitomycin C in patients undergoing surgery for watering eyes

A study on the efficacy of External Dacryocystorhinostomy with and without intraoperative application of Mitomycin-C in patients with primary nasolacrimal duct obstruction - Nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/11/077476

Enrollment

Registered

2024-11-28

Start date

Unknown

Completion date

Unknown

Last updated

2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H042- Epiphora

Interventions

Intervention1: Mitomycin C in External Dacryocystorhinostomy surgery: Application of 0.2 mg/ml Mitomycin C in a cotton tip applicator kept at the osteotomy site for 3 minutes of duration for one time

Eligibility

Inclusion criteria

Inclusion criteria: Patients with Primary Acquired Nasolacrimal Duct Obstruction

Exclusion criteria

Exclusion criteria: Past radiotherapy/chemotherapy Burns in nasolacrimal duct area History of naso-orbital trauma/ sinus surgery Lacrimal sac obstruction due to tumors Dacryolith Fibrotic sac TB/syphilis Deviated Nasal Septum to the same side Nasal polyps Hypertrophied turbinates Nasal Tumors Atrophic rhinitis Active/Chronic rhinosinusitis Revision DCR Pregnancy and lactation Deranged coagulation profile Allergy to mitomycin C Patients with less than 6 months of follow-up after surgery were excluded out of study Patients who did not consent for the enrolment into the study

Design outcomes

Primary

Measure	Time frame
resolution of epiphora post Dacryocystorhinostomy surgeryTimepoint: 6 months	—

Secondary

Measure	Time frame
free duct syringing post Dacryocystorhinostomy surgeryTimepoint: 6 months	—

Countries

India

Contacts

Public ContactDr Josephine Moni Sneha

Regional Institute of Ophthalmology, Egmore

maha0103@gmail.com9841988862

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026