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Bone graft with or without growth factor in bone defects

Comparative Evaluation of Efficacy of Demineralized Freeze Dried Bone Allograft (DFDBA)With or Without Recombinant Human Bone Morphogenetic Protein (Rh-BMP2) in the Treatment of Human Intrabony Periodontal Defects. A Clinico-Radiographic Study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/11/077464
Enrollment
20
Registered
2024-11-28
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis Health Condition 2: K03- Other diseases of hard tissues ofteeth Health Condition 3: Z789- Other specified health status

Interventions

Intervention1: rhBMP2 group: Open flap debridement with rhBMP-2 with or without DFDBA. Frequency-Patient recall after 1 week, 3 months and 6 months Total duration- 6 months for follow up Control Inte

Sponsors

Ginni Verma
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Age group ranging from 20-55 years. 2) Patients having minimum 20 teeth. 3) Clinical attachment loss � 3mm 4) Subjects of either sex having Generalised Chronic Periodontitis 5) Subjects who are systemically healthy with no contraindication to Periodontal surgery. 6) Presence of PD � 5mm with radiographic evidence of angular bone loss. 7) Compliant subjects.

Exclusion criteria

Exclusion criteria: 1) Subjects having any deleterious habits, such as smoking or tobacco chewing. 2) Subjects with history of any systemic disease. 3) Subjects who are sensitive to or shows any allergic reaction to any medication or any ingredient of the test- material. 4) Periodontal defect sites with one walled intra-bony defect. 5) Subjects showing unacceptable oral hygiene compliance during / after Phase-I therapy. 6) Pregnant or lactating females. 7) Subjects having undergone any periodontal therapy in the past three months. 8) Subjects prescribed with steroids/chemotherapy/radiotherapy. 9) Patient with any bleeding disorders. 10) Patient taking any medication which may affect wound healing. 11) Non-compliant subjects.

Design outcomes

Primary

MeasureTime frame
Clinical attachment level/ Relative attachment level, Radiographic bone fillTimepoint: 3 Months and 6 Months

Secondary

MeasureTime frame
Probing pocket depthTimepoint: 3 Months and 6 Months

Countries

India

Contacts

Public ContactGinni Verma

Subharti Dental College and Hospital

shivikhattri123@gmail.com9627600088

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 28, 2026