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Comparing epidural 0.125 percent bupivacaine infusion alone versus with 2 mcg per ml fentanyl for postoperative pain relief in abdominal surgeries under general anaesthesia

A comparative study of epidural 0.125 percent Bupivacaine infusion versus combination of epidural Bupivacaine 0.125 percent with 2 mcg per ml Fentanyl infusion for post operative pain relief in abdominal surgeries under general anaesthesia. - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/11/077442
Enrollment
100
Registered
2024-11-27
Start date
Unknown
Completion date
Unknown
Last updated
2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: epidural 0.125% bupivacaine infusion: Patients will receive an initial bolus of 8 ml of epidural analgesia infusion using 0.125% bupivacaine of 5 ml per hour. Intervention2: epidural 0.

Sponsors

Dr Paran Gupta
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anesthesiologists ASA grade I and II Patients who gave written informed consent Patients who are suitable for epidural analgesia based on preoperative assessment including coagulation profile evaluation and absence of contraindications to regional anaesthesia techniques Patients who are able to communicate effectively and provide reliable feedback regarding pain intensity and any adverse effects experienced during the study period Weight : 50 - 70 kg, Height : 150 - 180 cm, BMI : 20 - 30 kg/m2.

Exclusion criteria

Exclusion criteria: Patients younger than 18 years old. Patient not willing . Infection at the site of block. Patients with known allergy to local anaesthetics (such as bupivacaine) or opioids (such as fentanyl), or those with a history of adverse reactions to these medications. Patients with coagulation disorders or those receiving anticoagulant therapy. Patients with abnormal psychological profile on drugs like antileptic & other drugs acting on CNS . Patient with pre-existing neurological disorders (e.g., neuropathy, myopathy) that may affect the assessment of pain or increase the risk of neurological complications related to epidural analgesia. Patients who are unable to provide informed consent Patient who take analgesics for last 48 hours. Patient having chronic pain at the site of injection Base line blood pressure less than 100/60 mmHg

Design outcomes

Primary

MeasureTime frame
To Compare the post operative analgesic effect after administration of epidural bupivacaine 0.125% infusion and combination of epidural bupivacaine 0.125% with 2 mcg/ml fentanyl infusionTimepoint: From starting of infusion till 24 hours—

Secondary

MeasureTime frame
To Determine the requirement for rescue analgesia postoperatively when patient is on Epidural infusionTimepoint: From starting of infusion till 24 hours—

Countries

India

Contacts

Public ContactDr Arushi Saxena

Varun arjun medical college and rohilkhand hospital

mirbashir96@gmail.com9682536855

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026