Health Condition 1: C541- Malignant neoplasm of endometrium
Conditions
Interventions
Intervention1: NIL: NIL
Control Intervention1: NIL: NIL
Sponsors
AIIMS Rishikesh
Eligibility
Inclusion criteria
Inclusion criteria: 1. Histological diagnosis of endometrial cancer. 2. Execution of hysterectomy (with or without salpingo-oophorectomy) with or without nodal dissection 3. All stages of endometrial carcinoma (I-IV)
Exclusion criteria
Exclusion criteria: 1. Consent withdrawal 2. Patients with poor-quality slides/blocks (making pathological assessment difficult) 3. Poor quality of DNA obtained
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Number and percentage of cases with positive molecular markers (PoleMutated, MLH1, MSH2, MSH6, and PMS2, p53 abnormal). 2. Risk stratification based on surgico-pathological risk groups and molecular findings (low, intermediate, high-intermediate, high, and advanced/metastatic) ESMO-ESGO-ESTRO 2016 and ESGO-ESTRO-ESP 2020 risk group classification. 3. The number of cases that were upstaged or downstaged as per FIGO staging 2009 and 2023.Timepoint: Baseline, 1 year, 3 year, 5 years | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Number and percentage of cases who were multiple classifiers. 2. Involvement of myometrium, surgical margins, bilateral adnexa, cervical stroma, lymphovascular invasion, pelvic or para-aortic lymph nodes vis-a-vis molecular markers. 3. A number of women received adjuvant therapies in the form of brachytherapy, external beam radiotherapy, or chemoradiation. 4. Kaplan Meier curve for survival statistics. 5. L1CAM, ER, PR, and HER2-neu expression, CTNNB1, PTEN, E-cadherin, ARID1A mutations.Timepoint: 2 years | — |
Countries
India
Contacts
Public ContactKavita Khoiwal
AIIMS Rishikesh
Outcome results
None listed