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Locally delivered agents in chronic periodontitis

Comparative evaluation of locally delivered probiotics Saccharomyces boulardii-prebiotics Fructooligosaccharide mixture and tetracycline fibers as an adjunct to scaling and root planning in the management of patients with chronic periodontitis: A Randomised Clinical Trial - NIL

Status
Active, not recruiting
Phases
Phase 3Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/11/077408
Enrollment
32
Registered
2024-11-27
Start date
Unknown
Completion date
Unknown
Last updated
2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Scaling and root planing: Scaling and Root planing is done at baseline on all sites Control Intervention1: 1. Prebiotic-probiotic mixture (probiotic Saccharomyeces boulardii and prebio

Sponsors

Dr Chandrima Biswas
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Systemically healthy males and females participants of 25-55 years having 20 teeth or more except third molars having Chronic Periodontitis patient with at least two periodontal pockets = 5 mm with at least one pocket in each quadrant and clinical attachment level =1 mm

Exclusion criteria

Exclusion criteria: Patients with any systemic diseases or under antibiotics or anti-inflammatory drugs in the past 6 months or who have history of allergic reactions to tetracycline or Saccahromyces or Fructooligosaccharide or who have undergone periodontal therapy in the past 6 months or pregnant and Lactating women or Smokers and Tobacco users

Design outcomes

Primary

MeasureTime frame
Probing pocket depth, Clinical attachment level and colony forming units of Porphyromonas gingivalisTimepoint: baseline, 3 months and 6 months

Secondary

MeasureTime frame
Gingival index score (Loe and Silness) and Plaque index score (Silness and Loe)Timepoint: baseline, 3 months and 6 months

Countries

India

Contacts

Public ContactDr Chandrima Biswas

Sri Rajiv Gandhi College of Dental Sciences and Hospital

umeshyadalam@gmail.com9844269511

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026