Health Condition 1: E888- Other specified metabolic disorders
Conditions
Interventions
Intervention1: Probiotic: Probiotic capsule containing 10 billion CFU of strains of Lactobacillus, Streptococcus and Bifidobacterium for 3 months
Control Intervention1: Placebo: Microcrystalline Cellu
Sponsors
Gupte Hospital and Centre for Research in Reproduction
Eligibility
Inclusion criteria
Inclusion criteria: 1. Reproductive-aged women (19–37 years) with a confirmed diagnosis of PCOS according to the 2003 Rotterdam criteria and a body mass index (BMI) = 25 kg/m2 were included
Exclusion criteria
Exclusion criteria: Subjects with a history of chronic diseases, including diabetes, lung, pancreatic, renal, liver, or cardiovascular disease, thyroid disorders, hyperprolactinemia, Cushing’s syndrome, autoimmune diseases, allergy to probiotic products, use of antibiotics or multivitamin-mineral supplements within the last three months, and following specific diet or physical activity programs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Improvement in insulin resistance. 2. restoration of hormonal balance, with particular attention to changes in androgen levels (such as testosterone) and the luteinizing hormone (LH) to follicle-stimulating hormone (FSH) ratio, alongside other relevant reproductive hormonesTimepoint: At baseline and after 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| impact of probiotic supplementation on clinical characteristics (BMI, Hirsutism , Menstrual irregularity)Timepoint: After 12 weeks | — |
Countries
India
Contacts
Public ContactDr Preeti Arora
Research Division of Accurate Diagnostics Pvt. Ltd
Outcome results
None listed