A comparative study to assess the stress response of the patient for removing endotracheal tube by using two types of drugs

A prospective randomised controlled comparative clinical study of attenuation of hemodynamic responses to endotracheal extubation using lignocaine and combination of lignocaine and diltiazem - Nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/11/077212

Enrollment

Registered

2024-11-21

Start date

Unknown

Completion date

Unknown

Last updated

2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H652- Chronic serous otitis media Health Condition 2: H65-H75- Diseases of middle ear and mastoid

Interventions

Intervention1: Lignocaine: Administration of study drug lignocaine 1.5ml/kg body weight for one group of patients 2 minutes before extubation undergoing elective surgeries under general anaesthesia to

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade 1 and 2 patients Patients with modified mallampati scores 1 and 2 Patients posted for elective surgeries under general anaesthesia

Exclusion criteria

Exclusion criteria: Patients with difficult airway Patients with coexisting cardiovascular diseases Patients with heart rate less than 60 beats per minute Patients with blood pressure less than 100/60 mmhg Patients with documented hepatic or renal diseases Pregnant patients

Design outcomes

Primary

Measure	Time frame
Assess the hemodynamic responses to endotracheal extubation by monitoring heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressureTimepoint: 10 minutes	—

Secondary

Measure	Time frame
Assess the smoothness of extubationTimepoint: 10 minutes	—

Countries

India

Contacts

Public ContactDr SEENIVASAN V

Mysore medical college and research institute

drhgmanjunath@hotmail.com9448054368

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026