Comparison of two different doses of vaginal misoprostol for second trimester pregnancy termination in women with previous caesarean section

Efficacy and safety of two different doses of vaginal misoprostol for second trimester pregnancy termination in women with previous caesarean section- A Randomised Controlled Study - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/11/077177

Enrollment

Registered

2024-11-21

Start date

Unknown

Completion date

Unknown

Last updated

2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O048- (Induced) termination of pregnancywith other and unspecified complications

Interventions

Intervention1: MISOPROSTOL: 200mcg dose vaginally every 3 hrs for max of 5 doses if no result repeat of the 5 doses at 3 hr interval Control Intervention1: MISOPROSTOL: 400mcg dose vaginally every 3hr

Eligibility

Inclusion criteria

Inclusion criteria: 1.Singleton pregnancy 2.Previous one or two caesarean section 3.Period of gestation:12 week 0 days to 24 weeks 0 days

Exclusion criteria

Exclusion criteria: 1.Women with known heart disease 2.Women with low lying placenta

Design outcomes

Primary

Measure	Time frame
Rate of Sucess of abortion in two groups. Induction abortion interval in hours in both the regimens. Completeness of Abortion (need for surgical evacuation)- Percentage of cases requiring surgical evacuation or curettage due to retained products of conception in the two groups.Timepoint: start and completion of abortion process	—

Secondary

Measure	Time frame
1.Incidence of side effects related to misoprostol (nausea, vomiting). 2.Amount of blood loss (in ml): Amount of blood loss will be compared in both arms by using the pictorial method. 3.Number of women having scar dehiscence and scar complication 4.Post-abortive infection (Time frame- 7 days): rate of post-abortive infection in two groups. Timepoint: start and completion of abortion process till 7 days post abortion	—

Measure

Time frame

1.Incidence of side effects related to misoprostol (nausea, vomiting). 2.Amount of blood loss (in ml): Amount of blood loss will be compared in both arms by using the pictorial method. 3.Number of women having scar dehiscence and scar complication 4.Post-abortive infection (Time frame- 7 days): rate of post-abortive infection in two groups. Timepoint: start and completion of abortion process till 7 days post abortion

—

Countries

India

Contacts

Public ContactDr Krishna Agarwal

Lok Nayak Hospital

drkrishna.agarwal@gmail.com9968604350

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026