Health Condition 1: E282- Polycystic ovarian syndrome
Conditions
Interventions
None listed
Sponsors
Gujarat Technological University School of Pharmacy
Eligibility
Inclusion criteria
Inclusion criteria: The study involved PCOS-diagnosed and healthy controls from Gujarat clinics who will provide signed consent forms. Females aged 18-40 (Both inclusion) who are confirmed with a PCOS, based on the Rotterdam criteria. Women who are not pregnant or breastfeeding during the study period. Women who have no acute, hormonal, or neoplastic conditions and autoimmune diseases. Recruitment of healthy controls from hospitals, and educational institutions. Note: We will recruit age, diet, & BMI matched control. The same exclusion criteria will apply for the control.
Exclusion criteria
Exclusion criteria: The study will exclude smokers, alcoholics, non-vegetarians, and tobacco-chewing participants. This study will exclude participants who have used medications affecting insulin sensitivity (including those for blood pressure, steroids, cholesterol, hormonal contraceptives, antipsychotics, and antibiotics/prebiotics/probiotics) within the past 1 month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The purpose of this research provides an understanding of the role of bile acid metabolite analysis and gut microbiota alteration between PCOS patients and control groups.Timepoint: 1 Year | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessment and understanding the association of homeostasis model assessment for Insulin Resistance (HOMA-IR) scores between lean-obese PCOS patients and the control groups. Timepoint: 8 months;Understand the association of gut microbiota species with bile acid levels (correlation analysis using statistic software). Timepoint: 1 Year;Based on the analysis, select potential pathogenic factors contributing to the development of PCOS. Timepoint: 1 Year | — |
Countries
India
Contacts
Public ContactMs Foram Ravat
Gujarat Technological University School of Pharmacy
Outcome results
None listed