Comparison of single and double adjuvant drugs in nerve block of lower limb surgeries

Comparison Of Perineural Dexamethasone And Dexmedetomedine Vs Dexamethasone Only As An Adjuvant In Ultrasound Guided Sciatic Nerve Block Via Popliteal Approach In Orthopaedic Below Knee Surgeries A Double Blind Randomised Controlled Trial - nil

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/11/077119

Enrollment

Registered

2024-11-20

Start date

Unknown

Completion date

Unknown

Last updated

2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M859- Disorder of bone density and structure, unspecified

Interventions

Intervention1: dex-dexmed group: Two agents that is dexamethasone 4mg and dexmeditomedine 20 mcg will be added to 15 ml of 0.375 % ropivacaine to give popliteal sciatic nerve block Control Interventio

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age more than 18 years 2. Can provide consent 3. Below knee surgeries 4. ASA 1-3 physical status

Exclusion criteria

Exclusion criteria: 1. Local site infection 2. Local anaesthetic allergy 3. Pre-existing neurological deficit in lower limb 4. Peripheral vascular disease 5. Bleeding diasthesis/coagulopathy

Design outcomes

Primary

Measure	Time frame
To compare the duration of analgesia in patients undergoing below knee surgeries under neuraxial blockade after administration of sciatic nerve block without adjunct, with dexamethasone (single adjunct) and with 2 adjuncts (dexamethasone and dexmedetomidine).Timepoint: Post operative pain at 30 min., 2hour , 4 hour, 8 hour ,12 hour, 24 hour	—

Secondary

Measure	Time frame
1. To compare the opioid requirements in patients undergoing below knee surgeries under neuraxial blockade after administration of sciatic nerve block without adjunct, with dexamethasone (single adjunct) and with 2 adjuncts (dexamethasone and dexmedetomidine). 2. To compare the side effects of sciatic nerve block with no adjunct, single adjunct and 2 adjuncts. Timepoint: at the end of 24 hours after completion of surgery	—

Measure

Time frame

1. To compare the opioid requirements in patients undergoing below knee surgeries under neuraxial blockade after administration of sciatic nerve block without adjunct, with dexamethasone (single adjunct) and with 2 adjuncts (dexamethasone and dexmedetomidine). 2. To compare the side effects of sciatic nerve block with no adjunct, single adjunct and 2 adjuncts. Timepoint: at the end of 24 hours after completion of surgery

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Countries

India

Contacts

Public ContactDr Sachin Kumar

all india institute of medical sciences

sk2007696@gmail.com9871549343

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026