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To compare preoperative magnesium sulphate versus zinc sulphate gargle for prevention of postoperative sore throat

A randomized, double-blind, comparative study of preoperative magnesium sulphate versus zinc sulphate gargle for prevention of postoperative sore throat following endotracheal intubation - NIL

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/11/077022
Enrollment
150
Registered
2024-11-19
Start date
Unknown
Completion date
Unknown
Last updated
2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Magnesium Sulphate: Magnesium sulphate solution (20mg/kg dissolved in 20 ml of 5% dextrose. Intervention (gargles of magnesium sulphate solution) for 15 seconds. Given 15 minutes before

Sponsors

Vilasrao Deshmukh Government Medical College Latur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: American society of anaesthesiologists (ASA) physical status I & II. Patients undergoing elective surgeries under general anaesthesia with endotracheal intubation. Those willing to participate in the study.

Exclusion criteria

Exclusion criteria: Age more than 60 or less than 18 years. Patients having chronic cough, sore throat preoperatively and allergy to the study drug. Patient of ASA grade 3 and above. Pregnant females. Patient with surgeries around airway Patients with anticipated difficult intubation or with risk of aspiration of gastric contents

Design outcomes

Primary

MeasureTime frame
Sore throatTimepoint: Time after extubation at start, then at 2, 4, 6, 12 and 24 hours.

Secondary

MeasureTime frame
Hemodynamic changes- HR, SBP, DBP, MAPTimepoint: Time since induction of anaesthesia , intraoperatively at the interval of every 15 minutes & after extubation at start, then at 2, 4, 6, 12 & 24 hours.

Countries

India

Contacts

Public ContactDr Joshi Vyankatesh Shridharacharyaa

Vilasrao Deshmukh Government Medical College

vyankatesh93@rediffmail.com9049481707

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026