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Interface between Late Life Depression and Dementia

Assessing the role of neuroimaging connectomes and neuropsychological profiles in predicting cognitive decline in late-life depression: A prospective study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/11/076984
Enrollment
150
Registered
2024-11-19
Start date
Unknown
Completion date
Unknown
Last updated
2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F028- Dementia in other diseases classified elsewhere Health Condition 2: F334- Major depressive disorder, recurrent, in remission

Interventions

Intervention1: NIL: NIL Control Intervention1: NIL: NIL Control Intervention2: Healthy Human Volunteers: MRI

Sponsors

ICMR DHR Young Medical Faculty Ph.D. program 2024
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Group with Late life Depression- Persons meeting criteria for Major depressive disorder according to DSM 5 diagnostic guidelines Group with Dementia-Persons meeting criteria for Major neurocognitive disorder of mild severity according to DSM 5 diagnostic guidelines Group with Healthy volunteers- Persons without a diagnosis of Major depressive disorder and Major neurocognitive disorder

Exclusion criteria

Exclusion criteria: Group with Late life Depression-Persons with diagnosis of a preexisting psychiatric or neurological illness Group with Dementia-Persons with diagnosis of Major cognitive disorder due to Traumatic brain injury, Infective/Substance related etiology and those with early onset dementia Group with Healthy volunteers-Persons with diagnosis of a preexisting psychiatric or neurological illness

Design outcomes

Primary

MeasureTime frame
Cognitive DeclineTimepoint: Intake and 1 year follow up

Secondary

MeasureTime frame
Neuroimaging connectomeTimepoint: Baseline

Countries

India

Contacts

Public ContactShalini Perugu

St.Johns Medical College

shalini.p@stjohns.in7338539222

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026