Health Condition 1: J410- Simple chronic bronchitis Health Condition 2: J411- Mucopurulent chronic bronchitis Health Condition 3: J418- Mixed simple and mucopurulent chronic bronchitis Health Condition 4: J42- Unspecified chronic bronchitis Health Condition 5: J439- Emphysema, unspecified Health Condition 6: J441- Chronic obstructive pulmonary disease with (acute) exacerbation Health Condition 7: J449- Chronic obstructive pulmonary disease, unspecified Health Condition 8: J459- Other and unspeci
Conditions
Interventions
Intervention1: Centre-based Pulmonary Rehabilitation: Centre-based Pulmonary Rehabilitation (PR) will be delivered in groups (compliant with any social distancing requirements)
in single sex groups, where it is culturally appropriate. These sessions will be supervised by the therapist and will last up to two hours and include exercise components and group education. These su
Sponsors
Medical Research Council UK Applied Global Health Research Board
Eligibility
Inclusion criteria
Inclusion criteria: 1. Assessed by referring physician as having persistent and functionally limiting respiratory symptoms (mMRC =2) after optimization of pharmacological therapy. 2. Resident locally and willing to engage with either Centre-PR and Home-PR schedules if randomized to either of these groups. 3. Willing and able to provide written informed consent.
Exclusion criteria
Exclusion criteria: 1) People with non-respiratory causes for the symptoms (stable co-morbidity may be included if clinically appropriate). 2) Active TB infection. 3) Any condition that would increase risk (e.g. uncontrolled cardiac disease) interfere with PR (e.g. neurological disorders, severe arthritis, dementia) or be inappropriate (very severe frailty, end-of-life) 4) On-going, or completed PR (including other exercise program) within previous 18 months. 5) Living in the same house as another participant. 6) Unwilling or unable to provide informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Exercise capacity measured by the Endurance Shuttle Walking Test (ESWT) assessed post-PR intervention period. 2.HRQoL will be measured with the 50-item St Georges Respiratory Questionnaire (SGRQ). 3.Breathless will be assessed with the modified MRC Dyspnoea Scale (mMRC) ranging from 0-4. 4.The common co-morbid symptoms of anxiety and depression will be assessed with the Hospital Anxiety and Depression Score (HADS). 5.The impact of breathlessness on activities of daily living such as washing and dressing will be assessed with the London Chest Activities of Daily Living (LCADL). 6.The Global Physical Activity Questionnaire (GPAQ) assesses physical activity in the domains of work, leisure, or travel.Timepoint: 1. Baseline before randomization (T0) 2. At 12 weeks after completion of PR intervention (T+12; between 10-14 weeks) 3. At 6 months following intervention (T+26; between 24-30 weeks) | — |
Secondary
| Measure | Time frame |
|---|---|
| NilTimepoint: Nil | — |
Countries
Bangladesh, India, Malaysia
Contacts
Public ContactMr Paul Jebaraj
Christian Medical College, Vellore
Outcome results
None listed