A study to evaluate the expression of anti-microbial resistance genes in subgingival plaque samples in generalized periodontitis patients before and after using probiotic toothpaste.

Impact of Oral Probiotic Paste on Antimicrobial Resistance in Patients with Generalized Periodontitis: A Quasi-Experimental Study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Observational

Source

CTRI

Registry ID

CTRI/2024/11/076939

Enrollment

Registered

2024-11-18

Start date

Unknown

Completion date

Unknown

Last updated

2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: proof probiotic tooth paste: 1 month twice daily orally Control Intervention1: colgate tooth paste: 1 month twice daily orally

Eligibility

Inclusion criteria

Inclusion criteria: Systemically healthy patients with generalized periodontitis belonging to both sexes aged between 30-60 years will be selected

Exclusion criteria

Exclusion criteria: Pregnant and lactating females • Immunocompromised patient • Periodontal or orthodontic treatment at least 6 months before the start of the study • Use of antibiotics, corticosteroids, and anti ?inflammatory drugs within 3 months before sampling. • Smokers

Design outcomes

Primary

Measure	Time frame
Expression of ermT and vanX genesTimepoint: 1 MONTH	—

Secondary

Measure	Time frame
plaque index, bleeding on probingTimepoint: 1 month	—

Countries

India

Contacts

Public ContactAMBILI R

PMS College of Dental Science and Research

ambiliranjith@yahoo.com9447463676

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026