Sugammadex versus Neostigmine - the time to reversal of Rocuronium block.

Sugammadex versus Neostigmine - time to reversal of Rocuronium block in patients undergoing surgery under General Anaesthesia: A Randomized Controlled study - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/11/076937

Enrollment

Registered

2024-11-18

Start date

Unknown

Completion date

Unknown

Last updated

2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C509- Malignant neoplasm of breast of unspecified site Health Condition 2: C73- Malignant neoplasm of thyroid gland Health Condition 3: H958- Other intraoperative and postprocedural complications and disorders of the ear and mastoid process, not elsewhere classified

Interventions

Intervention1: Neostigmine: Neostigmine is a reversal agent works by inhibiting cholinesterase and increasing acetylcholine levels to compete with nondepolarising neuromuscular blocking agent. Interve

Eligibility

Inclusion criteria

Inclusion criteria: ASA PS 1 and 2 Elective surgeries under general anaesthesia ( thyroid , ENT and breast surgeries)

Exclusion criteria

Exclusion criteria: Emergency Surgery Pregnant patients Significant renal dysfunction, severe hepatic dysfunction, cardiac disease Anticipated difficult airway

Design outcomes

Primary

Measure	Time frame
Time taken from administering reversal agent (sugammadex or Neostigmine) to tracheal extubationTimepoint: At baseline	—

Secondary

Measure	Time frame
Compare the change in handgrip and Peak expiratory flow rate (PEFR) at 15min , 30 min and 60 min after reversal with Sugammadex or Neostigmine among patients undergoing general anaesthesiaTimepoint: 15min, 30 min and 60 min;Incidence of postoperative desaturation, upper airway obstruction, need for reintubation upto 1hour in PACU , 24 hours in ICU after reversal of Rocuronium induced neuromuscular blockade with Sugammadex and NeostigmineTimepoint: 24 hours	—

Measure

Time frame

Compare the change in handgrip and Peak expiratory flow rate (PEFR) at 15min , 30 min and 60 min after reversal with Sugammadex or Neostigmine among patients undergoing general anaesthesiaTimepoint: 15min, 30 min and 60 min;Incidence of postoperative desaturation, upper airway obstruction, need for reintubation upto 1hour in PACU , 24 hours in ICU after reversal of Rocuronium induced neuromuscular blockade with Sugammadex and NeostigmineTimepoint: 24 hours

—

Countries

India

Contacts

Public ContactPreethi R

All India institute of Medical Sciences, Bibinagar

ihteerp31@gmail.com9791546087

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026