Health Condition 1: J188- Other pneumonia, unspecified organism
Conditions
Interventions
Intervention1: Intravenous colistin plus Nebulized colistin: Intravenous colistin plus nebulized colistin along with STANDARD OF CARE(SOC) will be given in study cohort
Control Intervention1: Intraven
Sponsors
All India Institute of Medical Sciences Raipur
Eligibility
Inclusion criteria
Inclusion criteria: Patients aged 18 years or older patients admitted to critical care unit for more than 48 hours patients clinically suspected with ventilator associated pneumonia patients who will be receiving intravenous colistin and/or nebulized colistin
Exclusion criteria
Exclusion criteria: patients who will be discharged, leave against medical advise patient who are re-admitted to ICU
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical Improvement in terms of - 1.decreased FiO2 (20% decreases from baseline) 2.decreased PEEP (3 cm of water decrease from baseline) 3.total leukocyte count (within normal range as compared to baseline) 4. decreased secretions or decrease in number of suctioning as compared to baseline 4. procalcitonin levels less than 0.05mcg/litre or 80% decrease from baselineTimepoint: at baseline (for comparison), at end of3rd day | — |
Secondary
| Measure | Time frame |
|---|---|
| clinical improvementTimepoint: baseline, seventh day;median length of ICU StayTimepoint: date of admission in ICU & date of discharge/death/transferred out from ICU;median length of mechanical ventilationTimepoint: date of intubation & date of extubation;percentage of change in Clinical pulmonary infection score at admission & at completion of antibiotic therapyTimepoint: at admission & after antibiotic therapy is completed;all cause ICU mortalityTimepoint: between date of admission at ICU & date of discharge/death/transferred out;incidence of AKITimepoint: baseline, 3rd day & 7th day;incidence of bronchospasmTimepoint: after each instance of nebulization;culture conversion rateTimepoint: baseline & after completing antibiotic therapy | — |
Countries
India
Contacts
Public ContactDr Nitin R Gaikwad
All India Institute of Medical Sciences Raipur
Outcome results
None listed