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Effect of Selective Serotonin Reuptake Inhibitors on incidence of Acute Delirium and neuropsychiatric illness in ICU

Effect of prophylactic selective serotonin reuptake inhibitors on incidence of acute delirium in intensive care unit and neuropsychiatric illness in intensive care unit survivors - Nil

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/11/076910
Enrollment
150
Registered
2024-11-18
Start date
Unknown
Completion date
Unknown
Last updated
2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F22- Delusional disorders

Interventions

Intervention1: The intervention in this study is the administration of Selective Serotonin Reuptake Inhibitors (SSRIs), a class of antidepressant medications. These are prescribed to evaluate their ef

Sponsors

Intensive Care Unit
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patient in the age group of 18 to 60 years of either gender All ICU patients admitted to a medical or surgical ICU. Patients not on mechanical ventilation, GCS more than 14.

Exclusion criteria

Exclusion criteria: ICU stay was less than 72h. Patients with history of concurrent antipsychotic medications and drug abuser.

Design outcomes

Primary

MeasureTime frame
Incidence of acute delirium in patients on SSRI in ICUTimepoint: •ICU stay was less than 72h. •Patients with history of concurrent antipsychotic medications and drug abuser.

Secondary

MeasureTime frame
• To determine the incidence of neuropsychiatric illness following discharge from ICU in both groups(SSRI and Non SSRI)Timepoint: We will measure the following covariates as potential confounding variables: age, SSRI prescription prior to hospitalization, number of days in the hospital, sex, Sequential Organ Failure Assessment (SOFA) score , opiate dose in the preceding 72 hours & benzodiazepine dose in the prior 72 hours.

Countries

India

Contacts

Public ContactProf Monica Kohli
monica_kohli@rediffmail.com9839041228

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026