Comparison of Pain-Relieving Effects of IV Paracetamol vs. IV Magnesium Sulfate During General Anesthesia in Patients Undergoing Major Abdominal and Upper Limb Surgeries

A Comparative Study of the Analgesic Effects of Intravenous Paracetamol and Intravenous Magnesium Sulfate Under General Anesthesia in Patients Undergoing Major Abdominal and Upper Limb Surgeries - NIL

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/11/076902

Enrollment

100

Registered

2024-11-18

Start date

Unknown

Completion date

Unknown

Last updated

2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K802- Calculus of gallbladder without cholecystitis Health Condition 2: K20-K31- Diseases of esophagus, stomach and duodenum Health Condition 3: K36- Other appendicitis Health Condition 4: M958- Other specified acquired deformities of musculoskeletal system Health Condition 5: K420- Umbilical hernia with obstruction,without gangrene

Interventions

Intervention1: intravenous drugs given for preemptive analgesia: after induction and intubation of patient under General Anaesthesia ,Paracetamol 20 mg/kg iv over 10 min as infusion. Control Intervent

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patient scheduled for lower abdominal and lower limb surgeries under General anaesthesia. 2.Patient in ASA grade I and II. 3.Age between 18 - 65 years.

Exclusion criteria

Exclusion criteria: 1.Patient refusal for General anesthesia. 2.Patient refusal to enroll for the study. 3.Patients with cardiovascular disease, renal failure, hepatic dysfunction and chronic pulmonary disease. 4.Obesity (BMI = 30) 5.Bleeding disorders 6.History of allergy or sensitivity to any of the study drug

Design outcomes

Primary

Measure	Time frame
1.The role of intra operative Magnesium sulphate infusion as perioperative analgesic 2.To compare the efficacy of Magnesium sulphate infusion with infusion of Paracetamol in the quality and duration of postoperative analgesia in patients undergoing major surgeries under GA 3.Hemodynamic changes intra-operative 4.Side effects ,if any Timepoint: 1.The role of intra operative Magnesium sulphate infusion as perioperative analgesic 2.To compare the efficacy of Magnesium sulphate infusion with infusion of Paracetamol in the quality and duration of postoperative analgesia in patients undergoing major surgeries under GA 3.Hemodynamic changes intra-operative 4.Side effects ,if any	—

Measure

Time frame

1.The role of intra operative Magnesium sulphate infusion as perioperative analgesic 2.To compare the efficacy of Magnesium sulphate infusion with infusion of Paracetamol in the quality and duration of postoperative analgesia in patients undergoing major surgeries under GA 3.Hemodynamic changes intra-operative 4.Side effects ,if any Timepoint: 1.The role of intra operative Magnesium sulphate infusion as perioperative analgesic 2.To compare the efficacy of Magnesium sulphate infusion with infusion of Paracetamol in the quality and duration of postoperative analgesia in patients undergoing major surgeries under GA 3.Hemodynamic changes intra-operative 4.Side effects ,if any

—

Secondary

Measure	Time frame
decrease in VAS score Side Effects if anyTimepoint: till 24 hours post surgery	—

Countries

India

Contacts

Public ContactDR RAJ BAHADUR SINGH

IGIMS,Patna

virgodocraj36@yahoo.co.in07897844636

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026