None listed
Conditions
Interventions
Intervention1: Multimodal Prehabilitation - Study Arm: Monitored High Intensity Interval Training (HIIT) exercise, at least 2 weeks before surgery, practiced atleast once daily, taught to the donors b
Sponsors
Amrita Institute Of Medical Science
Eligibility
Inclusion criteria
Inclusion criteria: Voluntary healthy donors, between the age group of 18 to 60 years, having a body mass index (BMI) between 18 and 30 kg/m2, emotionally related to the patient, medically fit, and without any psychiatric illness, after being evaluated in a stepwise manner and deemed fit for donor hepatectomy through our institution’s protocol.
Exclusion criteria
Exclusion criteria: Donors undergoing liver donation for emergency Liver Transplant are Excluded Donors with fatty liver with LAI 9Liver Spleen Attenuation index) Less than (-9) at any point during their donor workup
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the peak ALT (Alanine Aminotransferase) between the two groups.Timepoint: 1 to 2 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Time of Normalization of Serum Bilirubin and PT-INR between the two groups.Timepoint: 1 to 2 weeks;Peak AST (Aspartate Aminotransferases), PT-INR(Prothrombin Time - International Normalized ratio) , Serum Bilirubin between the two groups.Timepoint: 1 to 2 weeks;Liver volume regeneration between the two groupsTimepoint: 2 to 3 weeks;Intraoperative liver biopsy (steatosis) between the two groups.Timepoint: At surgery;Liver-regeneration markers between the two groupsTimepoint: At Donor workup and at post op day 3;Blood loss , Hospital stay , Complication rate post surgery (Clavien Dindo Classification)Timepoint: 1 to 2 weeks;Rates of early graft dysfunction in recipients (Olthoff criteria)Timepoint: 1 to 2 weeks | — |
Countries
India
Contacts
Public ContactDr Vinaya Chandra C
Amrita Institute Of Medical Science
Outcome results
None listed