Health Condition 1: A159- Respiratory tuberculosis unspecified
Conditions
Interventions
Control Intervention1: Nil: Nil
Sponsors
Dr Mamta Muranjan
Eligibility
Inclusion criteria
Inclusion criteria: 1. Receiving isoniazid as a component of anti-tuberculosis treatment or tuberculosis prophylaxis. 2. Patients should have received isoniazid for at least 7 continuous days
Exclusion criteria
Exclusion criteria: 1. Patient not willing to give assent/written informed consent for study. 2. Patients infected with non-tuberculous mycobacterium. 3. Patients having liver diseases (acute and chronic). 4. Patient taking any concomitant drug undergoing acetylation and affecting isoniazid metabolism (for example – dapsone, procainamide, clonazepam, sulfamethazine)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Determination of prevalence of fast acetylators in children receiving Isoniazid. 2. Classification of pediatric tuberculosis patients into slow and fast acetylators based on acetylator index status. 3.Determination of correlation between the acetylator index and plasma levels of INH at 2 and 6 hours post dose in children with TB. 4. Determination of the relationship between acetylator status and adverse drug reactions of isoniazid in children with TB. Timepoint: 12 months | — |
Secondary
| Measure | Time frame |
|---|---|
| NilTimepoint: Nil | — |
Countries
India
Contacts
Public ContactDr Vedant Gaikwad
Seth GS Medical College and KEM Hospital
Outcome results
None listed