Health Condition 1: K137- Other and unspecified lesions of oral mucosa
Conditions
Interventions
Intervention1: Topical Platelet-rich Fibrin in orabase: 28 subjects diagnosed with Oral Lichen Planus will be treated with Topical Platelet-rich Fibrin in orabase thrice in a day till clinical resolut
Sponsors
Dr. Patel Ankita Navinbhai
Eligibility
Inclusion criteria
Inclusion criteria: 1.Subjects aged 18 to 60 years of both genders, diagnosed with symptomatic oral lichen planus clinically and histopathologically confirmed according to Modified WHO criteria. 2.Subjects who voluntarily consented to be a part of the study.
Exclusion criteria
Exclusion criteria: 1.Subjects who have received any topical treatment for OLP within the last 2 weeks or any systemic treatment for OLP within the past 3 months. 2.Subjects who are having Oral lichenoid reactions due to any medications, dental materials, diseases such as GVHD, tobacco, and so on. 3.Subjects with oral mucosal lesions other than OLP. 4.Subjects with a history of Anaemia (Hb less than 11g/dl) and Platelet count less than 150,000/mm3 5.Subjects with history of any medication, or conditions associated with bleeding disorders. 6.Subjects on anticoagulant therapy, chemotherapy or immunosuppressive medications. 7.Subjects with other autoimmune disease, malignancy, or hepatitis C virus infection. 8.Subjects for whom phlebotomy is contraindicated: evidence of cellulitis or abscess, presence of hematoma, presence of scar, recent venipuncture at the same location. 9.Subjects with systemic diseases where topical corticosteroids should be avoided. 10.Subjects receiving any systemic steroids for other systemic diseases. 11.Pregnant and lactating women. 12.Subjects with a habit of smoking
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS score, Thongprasom score, number, clinical appearance, and recurrence of lesionTimepoint: At the end of 0,1st week, 2nd week, 3rd week, 4th week, 5th week, 6th week, 7th week, 8th week, 1 month, 2nd month,3rd month, 4 th month, 5th month, 6th month | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse effects if anyTimepoint: At the end of 0,1st week, 2nd week, 3rd week, 4th week, 5th week, 6th week, 7th week, 8th week, 1 month, 2nd month,3rd month, 4 th month, 5th month, 6th month | — |
Countries
India
Contacts
Public ContactDr Suman B
Government Dental college and Research Institute, Bangalore
Outcome results
None listed