Health Condition 1: A90- Dengue fever [classical dengue]
Conditions
Interventions
Intervention1: Dexamethasone: 0.1mg IV once daily for a maximum of 5 days or until death or discharge (whichever is earlier)
Intervention2: Dexamethasone: 0.2mg once daily for a maximum of 5 days or
Sponsors
George Institute for Global Health, Australia
Eligibility
Inclusion criteria
Inclusion criteria: Eligible participants are adult (more than18yrs) patients admitted to the hospital with dengue and meeting one of the following criteria 1. Evidence of fluid leak in the form of raised hematocrit or presence of pleural effusion or ascites (detected using bedside ultrasonography) 2. Presence of thrombocytopenia (platelet count less than 150000) 3. Any evidence of organ dysfunction in the form of altered consciousness, need for O2 supplementation or need for non-invasive or invasive ventilation, vasopressors or kidney replacement therapy 4. Evidence of liver injury (AST or ALT levels ?5 times the upper limit of normal)
Exclusion criteria
Exclusion criteria: 1. 1.Already on long-term steroid treatment for more than 4 weeks. 2.Patients who are expected to die within the next 24 hrs. 3.Patients with the presence of an advanced directive for non-initiation of organ support 4.Duration from hospital admission more than 72hrs 5.Active tuberculosis or invasive fungal infection at the time of enrolment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome related to feasibility consent rate adherence to protocol adverse event profiles Timepoint: Day7 Day 28 Day 90 | — |
Secondary
| Measure | Time frame |
|---|---|
| Days alive and free of hospital until D90 Days alive and free or organ support until D28 Hospital and ICU length of stay Mean change from baseline in platelets count Timepoint: Day 4 and 7 Day 28 and 90 | — |
Countries
India
Contacts
Public ContactShani S Thankachen
Apollo Hospital ,Chennai
Outcome results
None listed