How Taking Meloxicam Before a Lidocaine and Epinephrine Injection, Combined with Mannitol, Affects Pain Relief in Dental Nerve Blocks: A Study

Effect Of Premedication With Meloxicam on Anaesthetic Efficacy of A Combination of Mannitol Plus LIdocaine With Epinephrine In Inferior Alveolar Nerve Block: A Randomized Control Trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/11/076797

Enrollment

Registered

2024-11-14

Start date

Unknown

Completion date

Unknown

Last updated

2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: Lidocaine Epinephrine: The intervention consists of a single administration of 2% lidocaine with 1:80000 epinephrine combined with 0.5 mol/L mannitol, with or without a 15 mg meloxicam

Eligibility

Inclusion criteria

Inclusion criteria: Adults aged 18-65 years with a vital, painful mandibular posterior tooth and a prolonged response to cold testing

Exclusion criteria

Exclusion criteria: AGE OUTSIDE 18-65, ALLERGIES TO SPECIFIC SUBSTANCES,PREGNANCY, SIGNIFICANT MEDICAL CONDITIONS, CERTAIN MEDICATIONS, ACTIVE PATHOSIS AT THE INJECTION SITE, OR INABILITY TO GIVE INFORMED CONSENT

Design outcomes

Primary

Measure	Time frame
To determine the effect of premedication with meloxicam on the anaesthetic efficacy of a combination of mannitol plus lidocaine with epinephrine in inferior alveolar nerve blocksTimepoint: Baseline, 6,12,24,72 hours	—

Secondary

Measure	Time frame
TO ASSESS THE ONSET TIME, DURATION OF ANESTHESIA, AND PATIENT COMFORTTimepoint: Baseline	—

Countries

India

Contacts

Public ContactDr Soanli Taneja

ITS-CDSR, MURADNAGAR

Sonalitaneja@its.edu.in9891688100

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026