Dexmedetomidine as adjuvant with levobupivacaine for spinal anaesthesia in lower limb surgeries - A study of it Effects when given mixed or one after another

Comparison of Subarachnoid Block in Mixed Versus Sequential Administration of Levobupivacaine and Dexmedetomidine in Lower Limb Surgeries: A Randomized Clinical Study - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/11/076796

Enrollment

Registered

2024-11-14

Start date

Unknown

Completion date

Unknown

Last updated

2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M808- Other osteoporosis with current pathological fracture Health Condition 2: M229- Unspecified disorder of patella Health Condition 3: M959- Acquired deformity of musculoskeletal system, unspecified

Interventions

Intervention1: Dexmedetomidine with hyperbaric Levobupivacaine (Premixed): After preanesthetic evaluation patients meeting inclusion criteria will be selected . operation theatre with all necessary eq

Eligibility

Inclusion criteria

Inclusion criteria: ASA – I/II/III Lower limb surgeries Duration of surgery: 2 to 2.5 hrs

Exclusion criteria

Exclusion criteria: Patients refusal. Patients with absolute and relative contraindications to spinal anaesthesia Local skin infection, Vertebral column abnormalities, bleeding disorders, cardiopulmonary disease, neuropathies Patients with allergy to study drugs. Pregnant and lactating females. BMI more than 30kg/ m2.

Design outcomes

Primary

Measure	Time frame
Sensory and Motor blockade characteristics Onset of sensory block at L1 dermatomal level Time to achieve maximum sensory level Time for two segment regression Total duration of sensory block Onset of motor blockade Time to achieve maximum motor blockade Duration of motor blockade Timepoint: Till 24 hours	—

Secondary

Measure	Time frame
To observe any changes in hemodynamic parameters like pulse rate, systolic blood pressure, diastolic blood pressure, mean areterial pressure, SpO2 perioperatively. Duration of effective analgesia - time from administration of drug intrathecally to pain score VAS = 4 postoperatively. Requirement of rescue analgesia in 24 hours. To observe any complications like Bradycardia, Hypotension, Respiratory depression, urinary retention, Shivering. Timepoint: till 24 hours	—

Measure

Time frame

To observe any changes in hemodynamic parameters like pulse rate, systolic blood pressure, diastolic blood pressure, mean areterial pressure, SpO2 perioperatively. Duration of effective analgesia - time from administration of drug intrathecally to pain score VAS = 4 postoperatively. Requirement of rescue analgesia in 24 hours. To observe any complications like Bradycardia, Hypotension, Respiratory depression, urinary retention, Shivering. Timepoint: till 24 hours

—

Countries

India

Contacts

Public ContactDr Kashmira Pander

Goverment Medical college Baroda

dr.kashmira13@gmail.com9099045151

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026