Comparision of two commonly used artificial tear substitutes: 0.5% Carboxymethylcellulose and 0.3% hydroxypropyl methylcellulose (HPMC)in patient with mild to moderate dry eye disease.

A randomized controlled trial comparing efficacy and safety of two tear substitutes 0.5 percent Carboxymethylcellulose (CMC) versus 0.3 percent hydroxypropyl methylcellulose (HPMC)in patient with mild to moderate dry eye disease. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/11/076778

Enrollment

148

Registered

2024-11-14

Start date

Unknown

Completion date

Unknown

Last updated

2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H048- Other disorders of lacrimal system

Interventions

Intervention1: Carboxymethyl cellulose (CMC): Dose :0.5% frequency : 4 times in a day duration on interval: 15 days Control Intervention1: hydroxypropyl methylcellulose (HPMC): dose : 0.3% frequency:

Eligibility

Inclusion criteria

Inclusion criteria: 1. Mild to moderate dry eye disease (At least in one eye) as per DEWS II Definition. 2. who is willing to take part in the study and ready to give informed consent form. 3. Patients with age between 18- 50 yrs 4. OSDI score15-30. 5. Schirmer test =5-10 mm at 5 min without anaesthesia

Exclusion criteria

Exclusion criteria: 1. Patient who cannot give informed consent. 2. Subject using contact lens. Page 9 of 13 3. Eyelid or blinking disorder. 4. Pregnant and lactating women. 5. Patient on local/systemic immunosuppressants. 6. Cancer and other clinically important diseases. 7. Having severe ocular surface disease. 8. Having ocular infection. 9. Ocular surgery and any concomitant eye disease. 10. History of allergy to any ocular medications/Any drugs.

Design outcomes

Primary

Measure	Time frame
To compare the efficacy of 0.5% carboxymethylcellulose and 0.3% hydroxypropyl methyl cellulose in terms of improvement in OSDI.Timepoint: 15 days	—

Secondary

Measure	Time frame
1. To compare the efficacy of 0.5% carboxymethylcellulose and 0.3% hydroxypropyl methyl cellulose in terms of corneal staining score, TBUT and Schirmer test readings. 2. To evaluate the safety of both the drugs. 3. To evaluate tear film proteomics following application of drugs.Timepoint: 15 days	—

Countries

India

Contacts

Public ContactDr Phulen Sarma

NIPER Gwahati

sangamniper@gmail.com7389783072

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026