Health Condition 1: B998- Other infectious disease
Conditions
Interventions
Intervention1: Norepinephrine: Titration of Norepinephrine dose based on pulsatility index on Transcranial Doppler
Control Intervention1: Pulsatility index on Transcranial Doppler: Titration of Norepi
Sponsors
Dayanand Medical College and Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Patient admitted to Intensive Care Units with early septic shock defined as within 6 hours of start of norepinephrine infusion
Exclusion criteria
Exclusion criteria: Age less than eighteen years Negative consent for participation in study Known cerebrovascular lesions and events like ischemic or hemorrhagic stroke History of head injury or other causes of increased ICP Known cerebral infection Known severe Carotid artery stenosis Other causes leading to encephalopathy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To titrate norepinephrine infusion using Trans cranial Doppler variable, pulsatility index ,to maintain optimal cerebral perfusion in septic shock and to assess the neurological outcome when TCD is used to titrate the norepinephrine infusion.Timepoint: Day 0, Day 1, Day 3 and after inotropes are stopped | — |
Secondary
| Measure | Time frame |
|---|---|
| ? Assessment of change in neurological status in patients with septic shock when PI is used to titrate norepinephrine dose. ? To assess the impact of TCD derived titration of nor epinephrine on length of ICU stay, ventilator free days, & outcome. Timepoint: Day 0, Day 1, Day 3 & when inotropes are stopped | — |
Countries
India
Contacts
Public ContactJASMINE KAUR KOCHHAR
Dayanand Medical College and Hospital, Ludhiana
Outcome results
None listed