Comparison of nebulised ropivacaine with nebulised dexmedetomidine and nebulised lignocaine in patients undergoing surgery under general anaesthesia

Comparison of Nebulised Ropivacaine 0.75 percent Versus Nebulised Dexmedetomidine and Nebulised lignocaine 4 percentin patients undergoing surgery under General Anesthesia. - Nil

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/11/076745

Enrollment

105

Registered

2024-11-13

Start date

Unknown

Completion date

Unknown

Last updated

2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Drug ropivacaine 0.75%, lignocaine , dexmedetomidine: Nebulisation is given Using ultrasonic nebuliser preoperatively and observe the haemodynamic changes at the time intubation , extub

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA grade I and II 2. Non- hypertensive 3.Non obese 4.MPC I and II 5.Surgeries lasting for at least upto 2 hours and not beyond 4 hours. 6. Elective surgeries

Exclusion criteria

Exclusion criteria: 1.Patients who refused to participate in study 2.patients age is less than 18 and not more than 60 years. 3. Patients with nasogastric tube. 4.Contraindication for the use of nitrous oxide. 5.Mallampati classification III and IV 6.hypertensive patients 7.ASA III AND IV 8.Patients with history of allergy to dexmedetomidine. 9.Daycare surgeries. 10. Patients with difficult airway where the anticipated duration of laryngoscopy exceeded 15 seconds. 11. Emergency surgeries.’ 12.Patients with history of cardiac,liver or renal disorders.

Design outcomes

Primary

Measure	Time frame
Monitor the hemodynamic changes in patients received ultrasonic nebulisation 4 % lignocaine at 10 minutes before and after nebulisation, 10 min, 20 minutes , 30 minutes till 120 minutes after intubation Monitor the hemodynamic changes of patients received ultrasonic nebulisation of dexmedetomidine 1 micro gram per kg at 10 minutes before and after nebulisation. 10 minutes, 20 minutes, 30 minutes till 90 minutes after intubation. Monitor hemodynamic changes in patients received ultrasonic nebulisation of 0.75 % ropivacaine at 10 minutes before and after nebulisation. 10 minutes, 20 minutes till 90 minutes after intubation. Timepoint: Observed assessed by 12 weeks	—

Measure

Time frame

Monitor the hemodynamic changes in patients received ultrasonic nebulisation 4 % lignocaine at 10 minutes before and after nebulisation, 10 min, 20 minutes , 30 minutes till 120 minutes after intubation Monitor the hemodynamic changes of patients received ultrasonic nebulisation of dexmedetomidine 1 micro gram per kg at 10 minutes before and after nebulisation. 10 minutes, 20 minutes, 30 minutes till 90 minutes after intubation. Monitor hemodynamic changes in patients received ultrasonic nebulisation of 0.75 % ropivacaine at 10 minutes before and after nebulisation. 10 minutes, 20 minutes till 90 minutes after intubation. Timepoint: Observed assessed by 12 weeks

—

Secondary

Measure	Time frame
To compare the hemodynamic parameters of nebulised ropivacaine versus nebulised lignocaine versus nebulised dexmedetomidine at extubation With 24 hours. Compare the cough response at the extubation and incidence of rate of postoperative sore throatTimepoint: Observed assessed by 12 weeks	—

Countries

India

Contacts

Public ContactKshirsagar sujit

B.j medical college , Sassoon hospital

ayshanaheema@gmail.com8848150750

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026