A study to find whether the drug Dexmedetomidine will help in preventing delirium which is a common postoperative mental state change in patients undergoing liver transplant surgery

Dexmedetomidine for the prevention of postoperative delirium in liver transplant recipients : A Randomized control study - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/11/076646

Enrollment

Registered

2024-11-11

Start date

Unknown

Completion date

Unknown

Last updated

2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K703- Alcoholic cirrhosis of liver Health Condition 2: K740- Hepatic fibrosis Health Condition 3: K746- Other and unspecified cirrhosis ofliver

Interventions

Intervention1: Group D: Dexmedetomidine treatment group – Group D (study group ). Participants will receive a continuous intravenous infusion of 0.5 microgram/kg/h of dexmedetomidine from induction of

Eligibility

Inclusion criteria

Inclusion criteria: Age 18 -60 Chronic liver disease patient undergoing elective allogenic liver transplantation Giving informed written consent

Exclusion criteria

Exclusion criteria: Severe circulatory instability Patients having hepatic encephalopathy on the morning of surgery Severe renal dysfunction undergoing renal replacement therapy before surgery Known allergy to the medication Transplant for acute liver Failure , acute on chronic liver failure Patients not giving consent

Design outcomes

Primary

Measure	Time frame
To compare the incidence of postoperative delirium on postoperative days 1 to 7 using CAM-ICU scoreTimepoint: To compare the incidence of postoperative delirium on postoperative days 1 to 7 using CAM-ICU score	—

Secondary

Measure	Time frame
To compare the incidence of postoperative cognitive dysfunction on day 7 using Mini Mental State Exam To compare the mean hemodynamic parameters during the various phases of liver transplant surgery To compare the mean requirement of vasopressors during these phases To compare the incidence of early allograft dysfunction on day 7 using Olthoff criteria Timepoint: day before surgery , intraoperative and postoperative days 1 to 7	—

Measure

Time frame

To compare the incidence of postoperative cognitive dysfunction on day 7 using Mini Mental State Exam To compare the mean hemodynamic parameters during the various phases of liver transplant surgery To compare the mean requirement of vasopressors during these phases To compare the incidence of early allograft dysfunction on day 7 using Olthoff criteria Timepoint: day before surgery , intraoperative and postoperative days 1 to 7

—

Countries

India

Contacts

Public ContactDr Udit Dhingra

Institute of Liver and Biliary Sciences Hospital

uddh1989@gmail.com8861987684

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026