Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: reduced vasopressor: Patients in the intervention group will be treated using the permissive hypotension strategy – a MAP target range of 60 - 65 mmHg whilst receiving continuous intrav
Sponsors
Swarnika Singh
Eligibility
Inclusion criteria
Inclusion criteria: Vasodilatory hypotension as assessed by treating clinician started infusion of vasopressors within prior 6 hours (if noradrenaline, then a minimum dose of 0.1 µg/ kg/ min) Adequate fluid resuscitation is completed or ongoing Vasopressors expected to continue for 6 hours or more as assessed by treating clinician for at least one hour
Exclusion criteria
Exclusion criteria: Vasopressors being used solely as therapy for bleeding, Acute ventricular failure (left or right) Post-cardiopulmonary bypass vasoplegia Ongoing treatment for brain injury or spinal cord injury
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical effectiveness: mortality at 90 daysTimepoint: Clinical effectiveness: mortality at 90 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality at discharge from the critical care unit and acute hospital Duration of survival to longest available follow-up Duration of advanced respiratory and renal support Timepoint: at discharge, 90 days | — |
Countries
India
Contacts
Public ContactDr Swati
Indira Gandhi Institute of Medical Sciences Patna
Outcome results
None listed