Health Condition 1: E114- Type 2 diabetes mellitus with neurological complications
Conditions
Interventions
Intervention1: duloxetine - Serotonin and noradrenaline reuptake inhibitors SNRI: Tab Duloxetine 60mg one tab od
administered to group I daily for 12 weeks
Control Intervention1: Gabapentine - Cycli
Sponsors
Rama Medical College Hospital and research centre
Eligibility
Inclusion criteria
Inclusion criteria: Patient of both the sexes 20-70 years of age, having Diabetes mellitus type 2 having diabetic polyneuropathy pain attending medicine OPD will be included in our study. Cooperative and conscious patient. Patient who will give written and informed consent and and are willing to go for follow up. Patient not taking any previous medication for diabetic neuropathy. Patient willing to undergo all pre and post treatment, investigation and willing to complete the prescribed course of treatment.
Exclusion criteria
Exclusion criteria: Patients having Diabetes mellitus type 2 and is diagnosed with other types of neuropathy and disorders & B12 deficiency will be excluded from the study. Patients who are already on medication for diabetic polyneuropathy. Patients with renal impairment, hepatic impairment and cardiac disease will be excluded from the study. Patients on drugs which increases the blood sugar level eg. steroids, adrenaline. Patients who are planning to conceive will be excluded. Pregnant and lactating women will be excluded. Mentally retarded and with altered state of mind will be excluded. Immunocompromised and drug abuse. Patients of Hepatic impairment. Patients having history of hypersensitivity to any of study drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS score Physical Examination Biochemical ExaminationTimepoint: Day 0, 4th week, 8th week, 12th week | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of LifeTimepoint: Day 0, 4th week, 8th week, 12th week | — |
Countries
India
Contacts
Public ContactDr Ruquaiya Khatoon
Rama Medical College Hospital and Research Centre, Kanpur
Outcome results
None listed