Management of gum loss using animal tissue combining with blood protein or tissue taken from roof of mouth

Comparative evaluation of the clinical outcomes of xenogeneic pericardial collagen membrane enriched with Advanced platelet rich fibrin plus And De-Epithelialized Gingival Graft Along with Coronally Advanced Flap in the treatment of gingival recession- A prospective study - Nil

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/11/076631

Enrollment

Registered

2024-11-11

Start date

Unknown

Completion date

Unknown

Last updated

2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K060- Gingival recession

Interventions

Intervention1: Group 1(CAF+A-PRF plus and XCM): Gingival recession sites treated with xenogeneic pericardial collagen membrane in combination with Advanced platelet rich fibrin membrane plus (CAF+A-PR

Eligibility

Inclusion criteria

Inclusion criteria: 1. Systemically healthy subjects with an age range of 25-50 years. 2. Individuals diagnosed with recession defects in maxillary anteriors and premolars (Cairo’s RT1, RT2 classes of recession). 3. Sites with minimum depth of recession more than or equal to 2mm. 4. Isolated or multiple adjoining recession involving less than or equal to 3 teeth

Exclusion criteria

Exclusion criteria: 1. Sites with probing pocket depth more than or equal to 4mm. 2.Teeth with mobility and/or associated with trauma from occlusion. 3. Sites with dental caries and prosthetic restorations. 4. Patients who exhibit unacceptable oral hygiene compliance during/or after phase ? therapy. 5. Smokers. 6. Pregnant and lactating women. 7.Patient known allergic response with Equine derived substances. 8.Patients with known platelet disorders or using any medication that are known to interfere with platelet function. 9. Patients with systemic conditions or disease influencing the course of periodontal disease and therapy.

Design outcomes

Primary

Measure	Time frame
1. To assess and compare the changes in the recession height (RH) from baseline to 6 months, within CAF+A-PRF plus and XCM group. 2. To assess and compare the changes in the recession height (RH) from baseline to 6 months, within CAF+DFGG group. 3. To assess and compare the changes in the recession height from baseline to 6 months between CAF+A-PRF plus and XCM and CAF+DFGG groups Timepoint: Baseline to 6months	—

Measure

Time frame

1. To assess and compare the changes in the recession height (RH) from baseline to 6 months, within CAF+A-PRF plus and XCM group. 2. To assess and compare the changes in the recession height (RH) from baseline to 6 months, within CAF+DFGG group. 3. To assess and compare the changes in the recession height from baseline to 6 months between CAF+A-PRF plus and XCM and CAF+DFGG groups Timepoint: Baseline to 6months

—

Secondary

Measure	Time frame
1.To assess and compare the percentage of complete root coverage (CRC%) achieved at 6 months between the treatment groups. 2.To assess and compare the patient perception regarding pain following the treatment modalities by using visual analogue scale score (VAS-P)Timepoint: 6 months	—

Countries

India

Contacts

Public ContactPolimera Sanathana

SRM dental college

anupamamds@gmail.com9677065517

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026