How Two Different Fluids Affect Blood Flow Before Spinal Anesthesia: A Comparison of Ringers Lactate and Sterofundin

Effect of Preloading on Inferior Vena Cava Collapsibility Index: A Comparative Observational Study of Ringers Lactate versus Sterofundin - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/11/076581

Enrollment

Registered

2024-11-11

Start date

Unknown

Completion date

Unknown

Last updated

2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: V279- Unspecified motorcycle rider injured in collision with fixed or stationary object in traffic accident

Interventions

Intervention1: Sterofundin: Sodium: 145 mEq/L Chloride: 127 mEq/L Potassium: 4 mEq/L Calcium: 2.5 mEq/L Magnesium: 1 mEq/L Acetate: 24 mEq/L Malate: 5 mEq/L Approximate Osmolarity: 309 mOsm/L Typical

Eligibility

Inclusion criteria

Inclusion criteria: Patients posted for lower limb orthopaedic surgery under spinal anaesthesia in supine position. patients with American society of anaesthesia physical status I and II Patients listed for elective surgery. Fasting for more than 8 hours.

Exclusion criteria

Exclusion criteria: patients with American society of anaesthesia physical status III and more. Pregnant women. Patients with abdominal mass or ascites.• Patients posted for emergency surgery. Contraindication for spinal anaesthesia. BMI more than 30 kilogram per meter square Patients who are on drugs which is affecting vascular status and tone. Example, Diuretics, Vasodilators and alpha blockers etc. Patients who are requiring over night hydration.

Design outcomes

Primary

Measure	Time frame
which fluid is better in terms of reduction of Inferior vena cava collapsibility index. Ringer lactate or sterofundineTimepoint: Preloading:IVCCI measured before fluid administration (fasting state). Post-Preloading: IVCCI measured immediately after 500 ml fluid administration. Post-Spinal Anesthesia: IVCCI measured at 15 minutes and 30 minutes after spinal anesthesia.	—

Secondary

Measure	Time frame
Incidence of hypotension after spinal anesthesia in both groups. Requirement for inotropes (example, ephedrine) to manage hypotension. Hemodynamic changes (heart rate, blood pressure) post-spinal anesthesia.Timepoint: Up to 30 minutes post-spinal anesthesia. During the first 30 minutes after spinal anesthesia. Monitored continuously, with specific measurements at 15 minutes and 30 minutes after spinal anesthesia.	—

Measure

Time frame

Incidence of hypotension after spinal anesthesia in both groups. Requirement for inotropes (example, ephedrine) to manage hypotension. Hemodynamic changes (heart rate, blood pressure) post-spinal anesthesia.Timepoint: Up to 30 minutes post-spinal anesthesia. During the first 30 minutes after spinal anesthesia. Monitored continuously, with specific measurements at 15 minutes and 30 minutes after spinal anesthesia.

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Countries

India

Contacts

Public ContactDr Deep Pareshkumar Unadkat

GMERS, medical college and hospital, Gotri, Vadodara

anupchandnani29@gmail.com9925436505

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026