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Comparing the effect of Donepezil and Memantine and combination of both in memory loss patients by using standard score .Participants are the patients coming to neurology OPD. Final outcome is the change in a standard score for memory loss.

Comparing the safety and efficacy of Donepezil,Memantine and fixed drug combination of Donepezil Memantine in dementia patients by using MoCA score - Prospective randomized open label study - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/11/076541
Enrollment
75
Registered
2024-11-11
Start date
Unknown
Completion date
Unknown
Last updated
2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G309- Alzheimers disease, unspecified

Interventions

Intervention1: Memantine: Assigned to receive Memantine 5mg OD HS for 3 months Intervention2: Donepezil: Assigned to receive Donepezil 5mg OD HS for 3 months Control Intervention1: fixed drug combinat

Sponsors

Dr Silpa S D
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patient Diagnosed with Dementia more than 45 years Both gender Willing to give informed consent for the study

Exclusion criteria

Exclusion criteria: Patient on Donepezil or memantine Altered behavioural components Parkinsonism Severely ill Unable to be assessed with critical flicker fusion apparatus Previous history of seizures Patients on calcium channel blocker and beta blockers Patients with gastric ulcer Patients with altered liver function and renal function

Design outcomes

Primary

MeasureTime frame
Change in MoCA scoreTimepoint: Once in a month—

Secondary

MeasureTime frame
Comparison of critical flicker fusion threshold changes with MoCA score changesTimepoint: Once in a month—

Countries

India

Contacts

Public ContactDr M Prakash

Govt stanley medical college

prakash18514@gmail.com8122810016

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026