Health Condition 1: I959- Hypotension, unspecified Health Condition 2: R098- Other specified symptoms and signsinvolving the circulatory and respiratory systems
Conditions
Interventions
Intervention1: NIL: NIL
Control Intervention1: NIL: NIL
Sponsors
IGIMSPATNA
Eligibility
Inclusion criteria
Inclusion criteria: The study selected consecutive adult patients admitted with the diagnosis of septic shock or within 24 h after septic shock onset in patients previously admitted for other causes. According to internationally accepted consensus definitions at the time of beginning of study , sepsis will be defined based on clinical evidence of infection and two or more of the following: fever axial temperature greater than 38°C or hypothermia axial temperature LESS THAN 36°C, tachycardia heart rate more than 90 beats per min, tachypnea more than 20 breaths per minute or need for mechanical ventilation, leukocytosis m ore than 12 000 cells/mm3 or leukopenia less than 4,000 cells/mm3, or a ratio of greater than 10% band cells to polymorphonuclear cells. Septic shock will be defined as sepsis with hypotension (mean arterial pressure less than 65 mm Hg and/or hypoperfusion represented by hyperlactatemia more than 2.0 mmol/L, irrespective of blood pressure, even after initial volume expansion and requiring vasopressors..
Exclusion criteria
Exclusion criteria: Other causes of shock,severe hepatopathy or coagulopathy platelets less than or equal to 20,000/mm3,international normalizated ratio more than 2.0, or activated partial thromboplastin time- aPTT more than 70 s, infective endocarditis, systemic sclerosis, and severe obstructive arterial disease. These criteria will be chosen to reduce the risks of possible hemorrhagic and ischemic complications of procedures. Patients with cardiac arrhythmias or active or severe bleeding will be also excluded from the protocol for assessing adrenergic stimulus that is increase of vasopressors doses.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| •To investigate the application of peripheral perfusion index (PPI) in early diagnosis and goal-directed therapy of septic shock, and to provide reference for the early clinical diagnosis and treatment of septic shock.Timepoint: •At the time of admission then every 6 hourly for first 24 hour then weekly and at last 28 days mortality benifit | — |
Secondary
| Measure | Time frame |
|---|---|
| early treatment for sepsis and mortality benefitTimepoint: patients admitted with the diagnosis of septic shock or within 24 h after septic shock onset in patients previously admitted for other causes. | — |
Countries
India
Contacts
Public ContactDR RAJ BAHADUR SINGH
IGIMS,Patna
Outcome results
None listed