Comparison of post operative pain relief after local injection of ropivacaine plus dexmedetomidine versus ropivacaine plus magnesium sulfate in patients undergoing lumbar spine surgeries

Comparison of local infiltration of ropivacaine plus dexmedetomidine versus ropivacaine plus magnesium sulfate for postoperative analgesia in patients undergoing lumbar spine surgeries. - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/11/076467

Enrollment

Registered

2024-11-08

Start date

Unknown

Completion date

Unknown

Last updated

2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M959- Acquired deformity of musculoskeletal system, unspecified

Interventions

Intervention1: Dexmedetomidine: 50 mcg of Dexmedetomidine equivalent to 0.5 ml as an additive to 15 ml of 0.75% Ropivacaine with 4.5 ml of normal saline for wound infiltration into paravertebral muscl

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anesthesiologists Physical status 1,2 scheduled for elective single/double level spine surgeries such as discectomy, laminectomy, posterior instrumentation under general anaesthesia.

Exclusion criteria

Exclusion criteria: Patient with severe medical conditions like 1.BMI = 30kg/m2 2.Inadequately controlled hypertension or diabetes mellitus 3.Asthma or COPD 4.Ischemic heart disease or other cardiac disorders 5.Kidney or liver diseases 6.Pre-existing cognitive impairment Neurological deficits or psychiatric disorders 7.Chronic use of antipsychotic medications or substance use disorders 8.Pregnancy 9.Patients allergic to ropivacaine, dexmedetomidine or magnesium sulfate

Design outcomes

Primary

Measure	Time frame
To compare the post operative analgesic effect using VAS score between group RD ( ropivacaine+ dexmedetomidine) and group RM( ropivacaine + MgSO4) To compare the mean duration of time to first rescue analgesia between group RD and RM Timepoint: at 0 minute, after shifting to post anaesthesia care unit (PACU), 30 minutes, 1st hour, 2nd hour, and thereafter at 4th hour, 6th hour, 12th hour, and 24th hour.	—

Measure

Time frame

To compare the post operative analgesic effect using VAS score between group RD ( ropivacaine+ dexmedetomidine) and group RM( ropivacaine + MgSO4) To compare the mean duration of time to first rescue analgesia between group RD and RM Timepoint: at 0 minute, after shifting to post anaesthesia care unit (PACU), 30 minutes, 1st hour, 2nd hour, and thereafter at 4th hour, 6th hour, 12th hour, and 24th hour.

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Secondary

Measure	Time frame
To evaluate total analgesic consumption between the study groups. To compare the post operative analgesic effect using VAS score between the gender. To assess hemodynamic variables between the study groups. To assess complication between the study groups. Timepoint: at 0 minute, after shifting to post anaesthesia care unit (PACU), 30 minutes, 1st hour, 2nd hour, and thereafter at 4th hour, 6th hour, 12th hour, and 24th hour.	—

Measure

Time frame

To evaluate total analgesic consumption between the study groups. To compare the post operative analgesic effect using VAS score between the gender. To assess hemodynamic variables between the study groups. To assess complication between the study groups. Timepoint: at 0 minute, after shifting to post anaesthesia care unit (PACU), 30 minutes, 1st hour, 2nd hour, and thereafter at 4th hour, 6th hour, 12th hour, and 24th hour.

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Countries

India

Contacts

Public ContactDr Yatish B

M S RAMAIAH MEDICAL COLLEGE AND HOSPITAL

yatishseeni@yahoo.co.in9886197658

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026