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Effect of additional usage of viscoelastic drug (HPMC 2%) in patients of cataract undergoing phacoemulsification cataract surgery and its outcome on corneal edema: An interventional randomized trial

Effect of Hydroxypropyl Methylcellulose (HPMC 2%) as an Adjuvant in Post Chopping the Nucleus in Phacoemulsification Surgery in Hard Cataract on Corneal Outcome - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/11/076442
Enrollment
66
Registered
2024-11-08
Start date
Unknown
Completion date
Unknown
Last updated
2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H251- Age-related nuclear cataract Health Condition 2: O- Medical and Surgical Health Condition 3: O- Medical and Surgical

Interventions

Intervention1: Adjuvant HPMC 2%: Softshell technique (with HPMC 2% followed by NaH 1.4%) with HPMC injection post chopping the nucleus as an adjuvant. Control Intervention1: without adjuvant HPMC 2%:

Sponsors

AIIMS Mangalagiri
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age more than 50 years. 2. Endothelial count more than 2000 cells/cumm. 3. Patients with nuclear sclerosis, cataract grade of 3 as per Emery Little classification. 4. Patients who is willing to undergo fellow eye cataract surgery for at least one month time 5. Normal macula examination

Exclusion criteria

Exclusion criteria: 1. Endothelial cell count less than 2000 cells/cu.mm 2. Patient who comes from far distance and may not able to come for one month follow up. 3. Presence of eye disease like unilateral uveitis, trauma, ICE, glaucoma, raised IOP more than 22 mm Hg, corneal scar, etc. 4. Nuclear sclerosis hard cataract of grade 4. 5. Single eyed. 6. Intumescent and white cataract 7. Any macular diseases

Design outcomes

Secondary

MeasureTime frame
1. corneal oedema grading 2. CCT using AS OCTTimepoint: Post treatment parameters measurements at day 1, day 3, day 7 and day 30:

Primary

MeasureTime frame
Post treatment parameters measurements at day 1, day 3, day 7 and day 30: 1.BCVA 2.IOP 3.Endothelial cell count 4. corneal oedema grading 5. CCT using AS OCT Timepoint: Post treatment parameters measurements at day 1, day 3, day 7 and day 30.

Countries

India

Contacts

Public ContactShubhangi SN Prasad

AIIMS Mangalagiri

bala.2xyx@gmail.com7087796565

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026