FindTrial
Sign In

Interventional study to compare the effectiveness of topical metformin 30% cream vs topical 0.025% tretinoin cream in the treatment of acanthosis nigricans-A randomized non inferiority assessor blinded study

Comparison of effectiveness of topical metformin 30 percent cream vs topical 0.025 percent tretinoin cream in the treatment of acanthosis nigricans - A randomized non inferiority assessor blinded study. - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/11/076396
Enrollment
74
Registered
2024-11-08
Start date
Unknown
Completion date
Unknown
Last updated
2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L83- Acanthosis nigricans

Interventions

Intervention1: TOPICAL METFORMIN 30% for a duration of 8 weeks: COMPARATIVE STUDY Control Intervention1: TOPICAL 0.025% TRETINOIN CREAM for a duration of 8 weeks: COMPARATIVE STUDY

Sponsors

SOA university
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All clinically diagnosed cases of acanthosis nigrican above 18 yrs of age

Exclusion criteria

Exclusion criteria: 1. Pregnancy and Lactation 2. Malignancy associated AN 3. Genetic or autoimmune AN 4. Syndromic AN 5. History of allergy to metformin 6. Type II diabetes mellitus, coagulopathy, liver disease), immunocompromised hosts, infection 7. Patients not on any topical or systemic therapy for AN in last 1 month

Design outcomes

Primary

MeasureTime frame
on photographic assessment and quantitative assessment using ANSC score.Timepoint: on photographic assessment and quantitative assessment to be done at 0,4,8,12 weeks—

Secondary

MeasureTime frame
safety profileTimepoint: It may be discontinued if patient denies because of severe pain , edema, erythema, blisters at 0,4,8,12 weeks—

Countries

India

Contacts

Public ContactBikash Ranjan Kar

ND SUM HOSPITAL

karbikash@gmail.com9937428181

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026