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Comparative study on different doses of vasapressor (phenylephrine) in treating hypotension in pregnancy induced hypertensive women undergoing casearean section under spinal block

A comparison of different doses of phenylephrine bolus injections in treatment of post spinal hypotension in pre eclampsia patients undergoing LSCS- RCT - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/11/076353
Enrollment
120
Registered
2024-11-07
Start date
Unknown
Completion date
Unknown
Last updated
2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O140- Mild to moderate pre-eclampsia Health Condition 2: O140- Mild to moderate pre-eclampsia

Interventions

Intervention1: phenylephrine: injection of 50 mcg of fixed dose of phenylephrine to treat post spinal hypotension in pregnant patients with pre eclampsia undergoing LSCS under spinal anesthesia .maxim

Sponsors

Bangalore medical college and research institute
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patient providing written informed consent voluntarily patient of 19-40 yrs American society of anesthesiologist grade 2 patient newly diagnosed to have Pre-eclampsia patient of pre eclampsia on treatment patient with weight 50- 80 kgs height of 150 - 170cm patient with pre eclampsia undergoing elective or emergency lower segment cesarean section in uncomplicated pregnancies under spinal anesthesia patient who develop hypotension following spinal anesthesia

Exclusion criteria

Exclusion criteria: Patients with ASA III or higher Allergic to the study drug Complicated Pregnancies -Multiple pregnancy, preterm LSCS, umbilical cord prolapse, HELLP, Eclampsia, Antepartum hemorrhage Bad obstetric history Inadequate level of spinal anesthesia Fetal growth restriction (estimated fetal weight less than 3rd centile for given gestational age [8]) Pre-existing HTN, Cerebral disease, Raised ICP, Severe PIH GDM, Epilepsy, Cardiac disease, Congestive heart failure resting heart rate less than 60 bpm Fetal anomalies in obstetric scans

Design outcomes

Primary

MeasureTime frame
Number of episodes of hypotension after giving the first dose of phenylephrineTimepoint: Blood pressure , heart rate , saturation will be monitored at an interval of 3 mins

Secondary

MeasureTime frame
Increase in MAP following the first dose of phenylephrineTimepoint: MAP measured immediately after administration of phenylephrine and and after 3 minutes of admisnistration

Countries

India

Contacts

Public ContactDr Nethra H N

Bangalore medical college and research institute

drnethrahn@gmail.com9902317865

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026