Use of steroids and Curcumin, clove oil lozenges in treatment of fibrosis of oral mucosa

Evaluation of efficacy of Curcumin and Clove oil lozenges in comparison to topical triamcinolone acetonide paste in treatment of oral submucous fibrosis: A randomized control trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/11/076330

Enrollment

Registered

2024-11-06

Start date

Unknown

Completion date

Unknown

Last updated

2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K135- Oral submucous fibrosis

Interventions

Intervention1: curcumin and clove oil lozenges: one lozenge containing Curcuma Longa -100 mg and Clove oil-4 mg dosage-1 lozenge QID for 60 days Control Intervention1: Triamcinolone acetonide oral pa

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients diagnosed with OSMF clinically and histopathologically 2.Patients with age group: 18 yr - 60yr 3.Patients with OSMF Stage II and Stage III (More et al classification 2011) 4: Patients who are not treated previously for OSMF.

Exclusion criteria

Exclusion criteria: 1. Patients with other mucosal lesions other than OSMF 2.Patients with trismus due to other reasons. 3.Patients who are currently on any treatment for OSMF 4.Patients with co-existing systemic ailments.

Design outcomes

Primary

Measure	Time frame
1.Benefit in improvement of mouth opening 2.Improvement of burning sensationTimepoint: 0, 15 days, 30 days 45 days and 60 days	—

Secondary

Measure	Time frame
Enhancement of overall quality of life of the patient.Timepoint: 60 days	—

Countries

India

Contacts

Public ContactRicha Srivastava

DY Patil school of dentistry

mandavi.waghmare@dypatil.edu08108069665

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026