Health Condition 1: R652- Severe sepsis
Conditions
Interventions
Intervention1: Nil: Nil
Control Intervention1: Nil: Nil
Sponsors
DrChakradharBN
Eligibility
Inclusion criteria
Inclusion criteria: 1) Patient in the age group of 18-70 years(Male and Female) 2) Written and informed consent from patient/family members 3)Patients with clinical diagnosis of Septic shock with adequate fluid resuscitation on ionotropes with ionotropic score more than 40 for atleast 2 hours, SOFA Score more than 8, Lactate level,more than 2.
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1. Pre-existing chronic liver disease, chronic renal failure (estimated Glomerular Filtration rate less than 30ml/min) 2. Previous history of RRT or CRRT .3 Immunodeficiency diseases such as tumors, connective tissue disease .4 Immunosuppressive treatment other than recommended dose of steroids in ICU. 5. Patients with Autoimmune disorders 6. Other modalities of blood purification techniques used 7. Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome: Asesment ni level of inflammatory markers (IL 6, TNF alpha) post haemoadsorption therapy.Timepoint: Pre Procedure and Post procedure After 6 hours, 12 hours, 24 hours,72 hours, 5th day,7th day | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Reduction in need of vasopressor requirements. . 2 .Change in SOFA score 3.Length of ICU stay 4.7 day mortalityTimepoint: 1. Reduction in need of vasopressor requirements ( Post procedure After 6 hours, 12 hours, 24 hours,72 hours, 5th day,7th day) 2 .Change in SOFA score(Pre Procedure and Post procedure After 6 hours, 12 hours, 24 hours,72 hours, 5th day,7th day) 3.Length of ICU stay 4.7 day mortality | — |
Countries
India
Contacts
Public ContactDR CHAKRADHAR B N
Dr.Ram Manohar Lohia Institute of Medical Sciences,Gomti Nagar, Lucknow-226010
Outcome results
None listed