Comparative assessment of two different doses of dexmedetomidine with magnesium sulphate for inhibition of the rise in blood pressure in response to laryngoscopy and intubation by measuring plasma cortisol levels under anaesthesia

Comparative assessment of two different doses of dexmedetomidine with magnesium sulphate for attenuation of the pressor response to laryngoscopy and intubation by assessment of hemodynamic parameters and plasma cortisol levels under Bi Spectral index guided anaesthesia - A randomized controlled study - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/11/076256

Enrollment

114

Registered

2024-11-04

Start date

Unknown

Completion date

Unknown

Last updated

2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Magnesium sulphate: Group M - Patients will be given IV MgSO4 loading dose 30 mg/kg in 50ml syringe over 10 minutes, starting 10 minutes prior to induction of anaesthesia Control Interv

Eligibility

Inclusion criteria

Inclusion criteria: All ASA I and II patients, aged 18-65 years, scheduled for elective surgery under general anesthesia.

Exclusion criteria

Exclusion criteria: Patients with a history of pulmonary disease like COPD, asthma, pregnancy, morbid obesity, unconotrolled diabetes mellitus, impaired kidney or liver function, anticipated difficult airway.

Design outcomes

Primary

Measure	Time frame
To study and compare the change in heart rate (HR) and systolic blood pressure (SBP), after administration of the study drug according to group allocation at different time intervals, maintaining Bispectral Index (BIS) values between 40-60.Timepoint: To study and compare the change in heart rate (HR) and systolic blood pressure (SBP), after administration of the study drug according to group allocation at different time intervals, maintaining Bispectral Index (BIS) values between 40-60.	—

Measure

Time frame

To study and compare the change in heart rate (HR) and systolic blood pressure (SBP), after administration of the study drug according to group allocation at different time intervals, maintaining Bispectral Index (BIS) values between 40-60.Timepoint: To study and compare the change in heart rate (HR) and systolic blood pressure (SBP), after administration of the study drug according to group allocation at different time intervals, maintaining Bispectral Index (BIS) values between 40-60.

—

Secondary

Measure	Time frame
To study and compare the change in- 1. Serum cortisol values obtained at baseline and at 3 minutes following endotracheal intubation in all the three study groups. 2. Diastolic blood pressure (DBP) at various time intervals in all the three study groups 3. Mean blood pressure (MBP) at various time intervals in all the three study groups Timepoint: 1 min, 2min, 3min, 5min, 7min	—

Countries

India

Contacts

Public ContactDr Mohd Shakir Naeem

Guru Teg Bahadur Hospital

mohdshakirnaeem@gmail.com9711022585

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026