Which biopsy is better for diagnosing lung fluid build-up: cryo or forceps?

Efficacy of semi-rigid thoracoscopic pleural cryo vs. forceps biopsy for evaluation of undiagnosed exudative pleural effusion. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/11/076233

Enrollment

Registered

2024-11-04

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J90- Pleural effusion, not elsewhere classified

Interventions

Intervention1: Semirigid thoracoscopic cryo biopsy: 11 mm semirigid thoracoscopic cryo-probe duration- one to three hours for the total procedure Control Intervention1: Semirigid thoracoscopic force

Eligibility

Inclusion criteria

Inclusion criteria: 1.Age more than 18 years 2.Presence of exudative pleural effusion 3.Absence of definitive diagnosis even after thoracocentesis and USG guided biopsy (if indicated)

Exclusion criteria

Exclusion criteria: 1. Unstable respiratory, cardiovascular, hemodynamic condition or uncorrected coagulation defects 2. Small pleural space or multiple adhesions visualized in ultrasound necessitating the use of rigid thoracoscopy.

Design outcomes

Primary

Measure	Time frame
To evaluate and compare the diagnostic efficacy of semi-rigid thoracoscopic pleural cryobiopsy versus forceps biopsy in cases of undiagnosed exudative pleural effusionsTimepoint: baseline, 1-2 weeks post procedure	—

Secondary

Measure	Time frame
1.To evaluate the major and minor complications of semi-rigid thoracoscopic pleural biopsy. 2. To assess and compare semi rigid thoracoscopic pleural cryobiopsy and forceps biopsy in terms of specimen size, procedure duration and ease of making histopathological diagnosisTimepoint: Immediate post procedure 1-2 weeks post procedure	—

Countries

India

Contacts

Public ContactAmal V Raj

Vardhman Mahavir Medical College & Safdarjung Hospital

dr.rohitkumar@mail.com9911218081

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 28, 2026