Health Condition 1: C00-D49- Neoplasms
Conditions
Interventions
Intervention1: Goal directed hemodynamic therapy group: In GDHT Group, intraoperative fluids therapy will be based on ICON (non invasive cardiac output monitor) parameters.
A protocolized approach wi
and CI and contractility indices within normal limits (based on patient’s BMI) .
2.Dobutamine (2-20 mcg/kg/min) if CI and contractility indices less than Normal range (based on patient’s BMI)
Sponsors
G B Pant institute of postgraduate medical education and research
Eligibility
Inclusion criteria
Inclusion criteria: ASA physical status 1&2 patients scheduled for elective craniotomy in sitting position
Exclusion criteria
Exclusion criteria: Patients with Ischemic Heart Disease, Cardiac arrythmias/ Intracardiac shunts/ Severe valvular heart disease, Uncontrolled hypertension, Renal or hepatic disease, Diabetic patients with autonomic dysfunction, Pregnancy, Cervical canal stenosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hypotension among the two groups evaluated by greater than 20% decrease in the mean arterial pressure from the baseline or a MAP less then 65mmHgTimepoint: Awake supine 5mins post induction Prior to preloading with colloid bolus After colloid preload Prior to change of position from supine to sitting 5mins after achieving the sitting position Every 30mins during surgery 5mins after repositioning the patient in supine position | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative variables: Hemodynamics Mean arterial pressure- by invasive intra arterial pressure monitoring Input crystalloids, colloids, blood and urine output Vasopressor and inotrope requirements (Ephedrine, Noradrenaline, Dobutamine) Blood loss and transfusion requirements Quality of brain relaxation will be evaluated by Brain Relaxation scale Difference in Serum Lactate levels from baseline and end of the surgery Difference in Serum NGAL levels from baseline and 2 hrs after the surgery Timepoint: Hemodynamic parameters and Quality of brain relaxation-Intraoperative period Difference in Serum Lactate- Baseline and end of the surgery Difference in Serum NGAL levels from baseline and 2 hrs after the surgery;Postoperative variables. Length of hospital and ICU stay, Occurrence of postoperative complications, Neurological outcomeTimepoint: Until 30days of postoperative period | — |
Countries
India
Contacts
Public ContactDr Monica S Tandon
GB pant institute of postgraduate medical education and research
Outcome results
None listed