Health Condition 1: I489- Unspecified atrial fibrillation and atrial flutter
Conditions
Interventions
Intervention1: Magnesium sulphate: Administration of Intravenous Injection of magnesium sulphate of 4500 mg standard dose in new onset atrial fibrillation
Control Intervention1: NIL: NIL
Sponsors
Rishwanth Raja P M
Eligibility
Inclusion criteria
Inclusion criteria: 1)Age 18 years or more 2)New onset atrial fibrillation(within 48 hours) of presentation,persist for atleast 30mins,ventricular rate 120 beats per minute or more without evidence of volume depletion 3)Normal Hemodynamics of Systoilc BP greater than 100mmhg and diastolic BP greater than 60mmhg
Exclusion criteria
Exclusion criteria: 1)Previous history of atrial tachyarrhythmias and antiarrhythmic drug use, 2)Permanent, Paroxysmal atrial fibrillation of unknown duration where also excluded, 3)Hemodynamic instability- a systolic blood pressure (SBP) of less than 90 mmHg and indicated for electrical cardioversion. 4)Patients will also be excluded if their Atrial fibrillation had a wide-complex ventricular response (potential Wolff-Parkinson-White preexcitation syndrome, 5)Chronic Kidney Disease. 6)Severe valvular heart diseases. 7)Sick sinus syndrome, or rhythm other than Atrial fibrillation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Conversion to normal sinus rhythm and rate control.Timepoint: 1 hour, 4 hours, 8 hours, 12 hours and 24 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Therapeutic response (referred to as resolution time), Differences in characteristics between magnesium responders and non-responders, To assess if there has been a reduction in the requirement for antiarrhythmic medicationsTimepoint: 1 hour, 4 hours, 8 hours, 12 hours and 24 hours | — |
Countries
India
Contacts
Public ContactRISHWANTH RAJA P M
Sri Ramachandra Institute of Higher Education and Research
Outcome results
None listed