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Role of cardiac marker - High Sensitivity Troponin I as a diagnostic tool in predicting Acute Coronary Syndrome

Diagnostic accuracy of High Sensitivity Troponin I (hsTnI) in predicting Acute coronary syndrome - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/11/076129
Enrollment
320
Registered
2024-11-01
Start date
Unknown
Completion date
Unknown
Last updated
2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I219- Acute myocardial infarction, unspecified

Interventions

Intervention1: Diagnostic accuracy of high sensitivity Troponin I (hsTnI) in predicting Acute coronary syndrome.: Intervention details following increase in High sensitivity Trop I (above the referenc

Sponsors

Institute funding The Madras Medical Mission Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All walk-in patients between 18 and 85 years of age presenting with Acute angina or equivalent symptoms suggestive of ACS who are evaluated and proceeded for cardiac triage by the clinical team of the Emergency Department of Madras Medical Mission

Exclusion criteria

Exclusion criteria: Less than 18 years of age History of Pregnancy, Patients with a history of surgery/trauma in the previous 4 weeks

Design outcomes

Primary

MeasureTime frame
To evaluate the sensitivity and specificity of hsTnI in diagnosing Acute coronary syndrome in patients with chest pain reporting to ER Timepoint: zero to two hours—

Secondary

MeasureTime frame
To validate the Rule in / Rule out algorithm for the early detection of Acute myocardial infarction (AMI) by incorporating hsTnI in a clinical protocol, for assessing patients reporting to emergency department of Cardiac tertiary care hospital by implementing 0–2hr algorithm using hsTrop I assay To evaluate AUC (Area under curve) with ROC for sensitivity vs specificity for the rule-in and rule-out of diagnosis of Myocardial Infarction(MI) To evaluate 99th percentile cut-off (URL) of hsTnI to the population group of MMM for the diagnosis of cardiac injury (Cardiac tertiary care hospital of South India) To evaluate the superiority of hsTnI as a early cardiac marker in comparison to conventional Troponin I and Triage Trop I POCT assay To study the significance of using VITROS hs Trop I in cardiac diseases other than AMI such as congestive heart failure, myocardial injury, myocarditis, etc. Timepoint: one month—

Countries

India

Contacts

Public ContactDr Chitra Sree Varadarajan

The Madras Medical Mission Hospital

chitrashree.v@gmail.com09444142211

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026