Health Condition 1: F102- Alcohol dependence
Conditions
Interventions
Intervention1: High definition transcranial direct current stimulation: We designed a custom made grid using a 4x1 configuration where electrodes were identified using 10-20 electrode placement system
Sponsors
Central Institute of Psychiatry
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients diagnosed with mental and behavioural disorders due to use of alcohol, dependence syndrome, currently using the substance (F10.24) as per International Classification of Disease 10th edition (ICD-10) Diagnostic Criteria for Research (WHO,1993). 2.Male 3.Age between 18-50 years 4.Clinical institute withdrawal assessment for alcohol revised (CIWA-ar) protocol score less than 10. 5.Ready to give informed consent
Exclusion criteria
Exclusion criteria: 1.Any comorbid substance abuse except nicotine and caffeine. 2.Participants having any comorbid psychiatric disorders, organic brain disorder, neurological, cardiovascular disorder or any serious physical problem. 3.Participants with hepatic derangements or impaired liver function test (LFT). 4.Participants having any contraindications for undergoing HDtDCS and fMRI study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in scores of craving as rated by Alcohol Craving Questionnaire(ACQ) and Obsessive-Compulsive Drinking Scale(OCDS) after completion and after 1 month of HDtDCS treatment.Timepoint: Reduction in scores of craving as rated by Alcohol Craving Questionnaire(ACQ) and Obsessive-Compulsive Drinking Scale(OCDS) after completion and after 1 month of HDtDCS treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in cue based BOLD activation as measured by fMRI after completion and 1 month of HDtDCS treatment.Timepoint: Changes in cue based BOLD activation as measured by fMRI after completion and 1 month of HDtDCS treatment. | — |
Countries
India
Contacts
Public ContactDr Sanjay Kumar Munda
Central Institute of Psychiatry
Outcome results
None listed