Health Condition 1: I607- Nontraumatic subarachnoid hemorrhage from unspecified intracranial artery
Conditions
Interventions
Intervention1: Total intravenous anaesthesia and Sevoflurane based inhalational anaesthesia: We plan to conduct a prospective randomized controlled trial to evaluate the effects of anesthetic agents o
Sponsors
Academic division,Sree Chitra Tirunal Institute for Medical Sciences and Technology
Eligibility
Inclusion criteria
Inclusion criteria: 1.American Society of Anesthesiologist (ASA) physical status class I- IV (class III & IV due to SAH) 2.Both gender 3Age 18-65 years, undergoing interventions for acute aSAH in the neurosurgery operation theatre or IR lab. 4.Patient’s or legally responsible relative’s consent
Exclusion criteria
Exclusion criteria: 1.ASA class III, IV (due to other systemic comorbidities), V 2.Severe or uncompensated cardiovascular, renal, hepatic or endocrine disease 3.Pregnancy, postpartum, lactating females 4.Drug allergy to Propofol or Fentanyl 5.Refusal to consent by patient or legally responsible relative. 6.Patients who are intubated and on mechanical ventilation 7.Emergency surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluate the levels of neuroinflammatory markers and systemic inflammatory markers pre and post anaesthesia exposure in patients undergoing interventions for acute aneurysmal subarachnoid haemorrhage.Timepoint: 21 months for recruitment 3 months for data analysis and compilation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluate the correlation of neuronal and systemic inflammatory markers with neurological and cognitive outcome in patients undergoing interventions for acute aneurysmal subarachnoid haemorrhageTimepoint: 21 months for recruitment 3 months for data analysis and compilation. | — |
Countries
India
Contacts
Public ContactDr Sravan Sreekumar
Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum
Outcome results
None listed