Management of gum loss in adults using tissue obtained from roof of their mouth or tissue obtained from animals

Comparative valuation of outcomes of xenogeneic pericardial collagen membrane enriched with injectable platelet rich fibrin(i-prf) and connective tissue graft in the treatment of gingival recession- A prospective clinical study - nil

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/10/076058

Enrollment

Registered

2024-10-29

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K060- Gingival recession

Interventions

Intervention1: Xenogeneic pericardial collagen membrane graft group: The gingival recession sites will be treated with xenogeneic pericardial collagen membrane(XCM) impregnated with injectable platele

Eligibility

Inclusion criteria

Inclusion criteria: 1. Systemically healthy subjects with an age range of 25-50 years. 2. Individuals diagnosed with recession defects in maxillary anteriors and premolars that is the Cairo’s RT1, RT2 classes of recession 3. Sites with minimum depth of recession more or equal to 4mm 4. Isolated or multiple adjoining recession involving less or equal to 3 teeth.

Exclusion criteria

Exclusion criteria: 1. Sites with probing pocket depth =4mm. 2.Teeth with mobility and/or associated with trauma from occlusion. 3. Sites with dental caries and prosthetic restorations. 4.Patients who exhibit unacceptable oral hygiene compliance during/or after phase ? therapy. 5.Smokers. 6.Pregnant and lactating women. 7.Patient known allergic response with xenogeneic derived substances. 8.Patients with known platelet disorders or using any medication that are known to interfere with platelet function. 9.Patients with systemic conditions or disease influencing the course of periodontal disease and therapy.

Design outcomes

Primary

Measure	Time frame
1. To assess and compare the changes in the recession height (RH) from baseline to 6 months, within XCM+i-PRF group. 2. To assess and compare the changes in the recession height (RH) from baseline to 6 months, within CAF+DFGG group. 3. To assess and compare the changes in the recession height from baseline to 6 months between XCM+i-PRF and CAF+DFGG groups.Timepoint: baseline and 6months	—

Secondary

Measure	Time frame
1. To assess and compare the percentage of complete root coverage (CRC%) achieved at 6 months between XCM+i-PRF and CAF+DFGG group. 2. To assess and compare the patient perception regarding pain following the treatment modalities by using visual analogue scale score (VAS-P)Timepoint: 6months	—

Countries

India

Contacts

Public ContactDr Anupama Tadepalli

SRM dental college

anupamamds@gmail.com9677065517

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026