The effect of Carboxymethylcelluose on corneal thickness in glaucoma and non glaucoma patients

The effect of 0.5 percentage Carboxymethylcellulose on corneal thickness in glaucoma and non glaucoma patients a stratified randomised control trial - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/10/076023

Enrollment

120

Registered

2024-10-29

Start date

Unknown

Completion date

Unknown

Last updated

2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H401- Open-angle glaucoma

Interventions

Intervention1: 0.5% CARBOXYMETHYLCELLULOSE: In all patients, detailed history as well as corneal topography with ASOCT will be done. 0.5%CARBOXY METHYL CELLULOSE drops will be given for the 2 groups-

Eligibility

Inclusion criteria

Inclusion criteria: Cases 1.Glaucoma patients using one or more of the same topical antiglaucoma medications for at least 3 months. Controls 1.Non glaucoma subjects who are matched for age (± 5) and gender of the glaucoma patients

Exclusion criteria

Exclusion criteria: 1.PATIENTS WITH ANY OTHER OCULAR OR CLINICALLY RELEVANT SYSTEMIC DISEASES (MEIBOMIAN GLAND DYSFUNCTION, SJOGREN SYNDROME, STEVEN JOHNSON SYNDROME). 2.HISTORY OF LUBRICANT INSTILLATION IN PAST 2 MONTHS 3.TREATMENT WITH ANY OTHER OPHTHALMIC DRUG EXCEPT TOPICAL ANTIGLAUCOMA DRUGS 4 WEEKS PRECEDING STUDY. 4.HISTORY OF OCULAR SURGERY IN PAST 6 MONTHS. KNOWN HYPERSENSITIVITY TO CARBOXYMETHYLCELLULOSE.

Design outcomes

Primary

Measure	Time frame
•To compare the effect of carboxy methylcellulose (0.5%) in glaucoma patients and non-glaucoma patients in terms of •central corneal thickness (CCT), •mid peripheral corneal thickness (PCT) •corneal epithelial thickness (CET) •central epithelial thickness to central corneal thickness ratio USING AS-OCTTimepoint: 1 MONTH	—

Secondary

Measure	Time frame
• To estimate the corneal thickness in glaucoma and non-glaucoma controls without lubricants.Timepoint: 1 MONTH	—

Countries

India

Contacts

Public ContactNamitha N Rose

Believers Church Medical College

leenalincy.varghese@gmail.com8762925383

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026