Health Condition 1: E282- Polycystic ovarian syndrome
Conditions
Interventions
Intervention1: Inj. Tetracosactide acetate stimulated LC-MS/MS steroid and steroid precursor panel
next generation sequencing: Patients will be called once for collection of venous blood samples for FSH,LH, prolactin, testosterone, TSH and for genetic analysis for CYP21A2 gene (targeted next genera
Sponsors
Department of Endocrinology Seth GS Medical College KEM Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Patients diagnosed with PCOS based on the Rotterdam criteria (Any two of the following): 1) Clinical (Modified Ferrimen Gallwey score >4) or biochemical hyperandrogenism (elevated total or free testosterone, androstenedione or DHEAS) 2) Oligo-anovulation (Oligo-amenorrhea (cycles >35 days apart or >8 menses in a year) 3) Polycystic ovarian morphology on Ultrasonography (= 20 follicles per ovary in either ovary = 10 cc ovarian volume) will be enrolled in the study.
Exclusion criteria
Exclusion criteria: Patients with PCOS due to other secondary causes like 1. prolactinoma 2. Cushing’s syndrome 3. Acromegaly will be excluded
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| proportion of PCOS patients with NCCAHTimepoint: 2 yrs | — |
Secondary
| Measure | Time frame |
|---|---|
| Hormonal parameters differentiating NCCAH & PCOSTimepoint: 2 yrs | — |
Countries
India
Contacts
Public ContactManjiri Karlekar
Seth G S Medical College and K E M Hospital
Outcome results
None listed